(Hypertension. 2000;36:471.)
© 2000 American Heart Association, Inc.
Scientific Contributions |
Possible Locus on Chromosome 18q Influencing Postural Systolic Blood Pressure Changes
From the Department of Epidemiology (J.S.P., K.M.R.), University of North Carolina, Chapel Hill; the Division of Preventive Medicine (A.O.), University of Alabama, Birmingham; Cardiovascular Genetics (S.C.H.), University of Utah, Salt Lake City; the Division of Epidemiology (L.D.A.), University of Minnesota, Minneapolis; the Section of Preventive Medicine and Epidemiology (L.D.), Boston University, Boston, Mass; and the Division of Biostatistics (M.A.P., D.C.R.), Washington University School of Medicine, St. Louis, Mo.
Correspondence to Dr James S. Pankow, Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Bank of America Center, Suite 306, 137 E Franklin St, Chapel Hill, NC 27514. E-mail jim pankow{at}unc.edupankow@unc.edu
Abstract—We conducted a
genome-wide scan for quantitative trait loci influencing the
systolic blood pressure, diastolic blood pressure,
and pulse responses to a postural challenge in 498 white sibling-pairs
from the Hypertension Genetic Epidemiology
Network, a multicenter study of the genetic susceptibility to
hypertension. All participants were hypertensive (systolic
blood pressure 
140 mm Hg, diastolic blood pressure
90 mm Hg, or on antihypertensive medications) with diagnosis
before age 60. Blood pressure and pulse were measured by an
oscillometric method after a 5-minute rest in a supine position and
again immediately on standing. The genome scan included a total of 387
autosomal short-tandem-repeat polymorphisms typed by the National
Heart, Lung, and Blood Institute Mammalian Genotyping Service at
Marshfield. We used multipoint variance-components linkage
analysis to identify possible quantitative trait loci
influencing postural change phenotypes after adjusting for sex,
age, and use of antihypertensive medications. There was suggestive
evidence for linkage on chromosome 18q for the postural
systolic blood pressure response (maximum logarithm of the odds
score=2.6 at 80 centiMorgans). We also observed a maximum logarithm of
the odds score of 1.9 for the systolic blood pressure response
and 1.7 for the diastolic blood pressure response on
chromosome 6p. The marker that demonstrated the strongest evidence for
linkage for the systolic blood pressure response (D18S858) lies
within 20 centiMorgans of a marker previously linked to rare familial
orthostatic hypotensive syndrome. Our findings indicate
that there may be 1 or more genes on chromosome 18q that regulate
systolic blood pressure during the
physiological recovery period after a postural
stressor.
Key Words: posture • blood pressure • heart rate • hypertension • linkage • chromosome mapping
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