This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Pankow, J. S. Articles by Rao, D. C. Search for Related Content PubMed PubMed Citation Articles by Pankow, J. S. Articles by Rao, D. C. Pubmed/NCBI databases UniSTS Medline Plus Health Information High Blood Pressure Related Collections Epidemiology Autonomic, reflex, and neurohumoral control of circulation Genetics of cardiovascular disease

(Hypertension. 2000;36:471.)
© 2000 American Heart Association, Inc.

Scientific Contributions

Possible Locus on Chromosome 18q Influencing Postural Systolic Blood Pressure Changes

James S. Pankow; Kathryn M. Rose; Albert Oberman; Steven C. Hunt; Larry D. Atwood; Luc Djoussé; Michael A. Province; D. C. Rao

From the Department of Epidemiology (J.S.P., K.M.R.), University of North Carolina, Chapel Hill; the Division of Preventive Medicine (A.O.), University of Alabama, Birmingham; Cardiovascular Genetics (S.C.H.), University of Utah, Salt Lake City; the Division of Epidemiology (L.D.A.), University of Minnesota, Minneapolis; the Section of Preventive Medicine and Epidemiology (L.D.), Boston University, Boston, Mass; and the Division of Biostatistics (M.A.P., D.C.R.), Washington University School of Medicine, St. Louis, Mo.

Correspondence to Dr James S. Pankow, Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Bank of America Center, Suite 306, 137 E Franklin St, Chapel Hill, NC 27514. E-mail jim pankow{at}unc.edupankow@unc.edu

Abstract—We conducted a genome-wide scan for quantitative trait loci influencing the systolic blood pressure, diastolic blood pressure, and pulse responses to a postural challenge in 498 white sibling-pairs from the Hypertension Genetic Epidemiology Network, a multicenter study of the genetic susceptibility to hypertension. All participants were hypertensive (systolic blood pressure 140 mm Hg, diastolic blood pressure 90 mm Hg, or on antihypertensive medications) with diagnosis before age 60. Blood pressure and pulse were measured by an oscillometric method after a 5-minute rest in a supine position and again immediately on standing. The genome scan included a total of 387 autosomal short-tandem-repeat polymorphisms typed by the National Heart, Lung, and Blood Institute Mammalian Genotyping Service at Marshfield. We used multipoint variance-components linkage analysis to identify possible quantitative trait loci influencing postural change phenotypes after adjusting for sex, age, and use of antihypertensive medications. There was suggestive evidence for linkage on chromosome 18q for the postural systolic blood pressure response (maximum logarithm of the odds score=2.6 at 80 centiMorgans). We also observed a maximum logarithm of the odds score of 1.9 for the systolic blood pressure response and 1.7 for the diastolic blood pressure response on chromosome 6p. The marker that demonstrated the strongest evidence for linkage for the systolic blood pressure response (D18S858) lies within 20 centiMorgans of a marker previously linked to rare familial orthostatic hypotensive syndrome. Our findings indicate that there may be 1 or more genes on chromosome 18q that regulate systolic blood pressure during the physiological recovery period after a postural stressor.

Key Words: posture • blood pressure • heart rate • hypertension • linkage • chromosome mapping

This article has been cited by other articles:

				F. Luo, Y. Wang, X. Wang, K. Sun, X. Zhou, and R. Hui A Functional Variant of NEDD4L Is Associated With Hypertension, Antihypertensive Response, and Orthostatic Hypotension Hypertension, October 1, 2009; 54(4): 796 - 801. [Abstract] [Full Text] [PDF]

				M. D. Johnson, L. He, D. Herman, H. Wakimoto, C. A. Wallace, V. Zidek, P. Mlejnek, A. Musilova, M. Simakova, J. Vorlicek, et al. Dissection of Chromosome 18 Blood Pressure and Salt-Sensitivity Quantitative Trait Loci in the Spontaneously Hypertensive Rat Hypertension, September 1, 2009; 54(3): 639 - 645. [Abstract] [Full Text] [PDF]

				C. Moreno, M. L. Kaldunski, T. Wang, R. J. Roman, A. S. Greene, J. Lazar, H. J. Jacob, and A. W. Cowley Jr. Multiple blood pressure loci on rat chromosome 13 attenuate development of hypertension in the Dahl S hypertensive rat Physiol Genomics, October 19, 2007; 31(2): 228 - 235. [Abstract] [Full Text] [PDF]

				D. K. Arnett, A. E. Baird, R. A. Barkley, C. T. Basson, E. Boerwinkle, S. K. Ganesh, D. M. Herrington, Y. Hong, C. Jaquish, D. A. McDermott, et al. Relevance of Genetics and Genomics for Prevention and Treatment of Cardiovascular Disease: A Scientific Statement From the American Heart Association Council on Epidemiology and Prevention, the Stroke Council, and the Functional Genomics and Translational Biology Interdisciplinary Working Group Circulation, June 5, 2007; 115(22): 2878 - 2901. [Abstract] [Full Text] [PDF]

				B. Guzman, B. Cormand, M. Ribases, D. Gonzalez-Nunez, A. Botey, and E. Poch Implication of Chromosome 18 in Hypertension by Sibling Pair and Association Analyses: Putative Involvement of the RKHD2 Gene Hypertension, November 1, 2006; 48(5): 883 - 891. [Abstract] [Full Text] [PDF]

				S. J. Bielinski, A. I. Lynch, M. B. Miller, A. Weder, R. Cooper, A. Oberman, Y.-D. I. Chen, S. T. Turner, M. Fornage, M. Province, et al. Genome-Wide Linkage Analysis for Loci Affecting Pulse Pressure: The Family Blood Pressure Program Hypertension, December 1, 2005; 46(6): 1286 - 1293. [Abstract] [Full Text] [PDF]

				O. Staub and F. Verrey Impact of Nedd4 Proteins and Serum and Glucocorticoid-Induced Kinases on Epithelial Na+ Transport in the Distal Nephron J. Am. Soc. Nephrol., November 1, 2005; 16(11): 3167 - 3174. [Abstract] [Full Text] [PDF]

				C. J. Russo, E. Melista, J. Cui, A. L. DeStefano, G. L. Bakris, A. J. Manolis, H. Gavras, and C. T. Baldwin Association of NEDD4L Ubiquitin Ligase With Essential Hypertension Hypertension, September 1, 2005; 46(3): 488 - 491. [Abstract] [Full Text] [PDF]

				F. Fouladkou, R. Alikhani-Koopaei, B. Vogt, S. Y. Flores, L. Malbert-Colas, M.-C. Lecomte, J. Loffing, F. J. Frey, B. M. Frey, and O. Staub A naturally occurring human Nedd4-2 variant displays impaired ENaC regulation in Xenopus laevis oocytes Am J Physiol Renal Physiol, September 1, 2004; 287(3): F550 - F561. [Abstract] [Full Text] [PDF]

				C. A. Mein, M. J. Caulfield, R. J. Dobson, and P. B. Munroe Genetics of essential hypertension Hum. Mol. Genet., April 1, 2004; 13(90001): R169 - 175. [Abstract] [Full Text] [PDF]

				K. E. North, K. M. Rose, I. B. Borecki, A. Oberman, S. C. Hunt, M. B. Miller, J. Blangero, L. Almasy, and J. S. Pankow Evidence for a Gene on Chromosome 13 Influencing Postural Systolic Blood Pressure Change and Body Mass Index Hypertension, April 1, 2004; 43(4): 780 - 784. [Abstract] [Full Text] [PDF]

				S. B. Harrap, J. S. Cui, Z. Y. H. Wong, and J. L. Hopper Familial and Genomic Analyses of Postural Changes in Systolic and Diastolic Blood Pressure Hypertension, March 1, 2004; 43(3): 586 - 591. [Abstract] [Full Text] [PDF]

				M. Gong, H. Zhang, H. Schulz, Y.-A. Lee, K. Sun, S. Bahring, F. C. Luft, P. Nurnberg, A. Reis, K. Rohde, et al. Genome-wide linkage reveals a locus for human essential (primary) hypertension on chromosome 12p Hum. Mol. Genet., June 1, 2003; 12(11): 1273 - 1277. [Abstract] [Full Text] [PDF]

				R. S. Cooper, A. Luke, X. Zhu, D. Kan, A. Adeyemo, C. Rorimi, N. Bouzekri, and R. Ward Genome Scan Among Nigerians Linking Blood Pressure to Chromosomes 2, 3, and 19 Hypertension, November 1, 2002; 40(5): 629 - 633. [Abstract] [Full Text] [PDF]

				E. Kamynina and O. Staub Concerted action of ENaC, Nedd4-2, and Sgk1 in transepithelial Na+ transport Am J Physiol Renal Physiol, September 1, 2002; 283(3): F377 - F387. [Abstract] [Full Text] [PDF]

				S. C. Hunt, R. C. Ellison, L. D. Atwood, J. S. Pankow, M. A. Province, and M. F. Leppert Genome Scans for Blood Pressure and Hypertension: The National Heart, Lung, and Blood Institute Family Heart Study Hypertension, July 1, 2002; 40(1): 1 - 6. [Abstract] [Full Text] [PDF]

				K. Kristjansson, A. Manolescu, A. Kristinsson, T. Hardarson, H. Knudsen, S. Ingason, G. Thorleifsson, M. L. Frigge, A. Kong, J. R. Gulcher, et al. Linkage of Essential Hypertension to Chromosome 18q Hypertension, June 1, 2002; 39(6): 1044 - 1049. [Abstract] [Full Text] [PDF]

				P. A. Doris Hypertension Genetics, Single Nucleotide Polymorphisms, and the Common Disease:Common Variant Hypothesis Hypertension, February 1, 2002; 39(2): 323 - 331. [Abstract] [Full Text] [PDF]

				K. Ranade, K.-D. Wu, C.-M. Hwu, C.-T. Ting, D. Pei, R. Pesich, J. Hebert, Y.-D. I. Chen, R. Pratt, R. Olshen, et al. Genetic variation in the human urea transporter-2 is associated with variation in blood pressure Hum. Mol. Genet., September 1, 2001; 10(19): 2157 - 2164. [Abstract] [Full Text] [PDF]

				T. Rankinen, P. An, T. Rice, G. Sun, Y. C. Chagnon, J. Gagnon, A. S. Leon, J. S. Skinner, J. H. Wilmore, D. C. Rao, et al. Genomic Scan for Exercise Blood Pressure in the Health, Risk Factors, Exercise Training and Genetics (HERITAGE) Family Study Hypertension, July 1, 2001; 38(1): 30 - 37. [Abstract] [Full Text] [PDF]

				F. C. Luft and A. Busjahn Peaks and Valleys Hypertension, July 1, 2001; 38(1): 38 - 40. [Full Text] [PDF]

				L. D. Atwood, P. B. Samollow, J. E. Hixson, M. P. Stern, and J. W. MacCluer Genome-Wide Linkage Analysis of Pulse Pressure in Mexican Americans Hypertension, February 1, 2001; 37(2): 425 - 428. [Abstract] [Full Text] [PDF]

				R. N. Re On the Sequencing of the Human Genome Hypertension, October 1, 2000; 36(4): 469 - 470. [Full Text] [PDF]