This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Matsumura, K. Articles by Abe, I. Search for Related Content PubMed PubMed Citation Articles by Matsumura, K. Articles by Abe, I. Pubmed/NCBI databases Substance via MeSH Related Collections Autonomic, reflex, and neurohumoral control of circulation

(Hypertension. 2000;36:1040.)
© 2000 American Heart Association, Inc.

Scientific Contributions

Central Cardiovascular Action of Neuropeptide Y in Conscious Rabbits

Kiyoshi Matsumura; Takuya Tsuchihashi; Isao Abe

From the Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Correspondence to Kiyoshi Matsumura, MD, Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan. E-mail matsumk{at}intmed2.med.kyushu-u.ac.jp

Abstract—We determined the central interactions of neuropeptide Y and leptin on cardiovascular and sympathetic responses in conscious rabbits. Intracerebroventricular injections of neuropeptide Y (0.1 and 1 nmol/40 µL) elicited dose-related decreases in arterial pressure and renal sympathetic nerve activity without a significant change in heart rate. Peak depressor or sympathoinhibitory responses of mean arterial pressure and renal sympathetic nerve activity (-13.0±1.5 mm Hg and -27.6±4.9%) were observed at 25 and 20 minutes after intracerebroventricular injection of 1 nmol of neuropeptide Y, respectively. Pretreatment with intracerebroventricular injection of leptin (3 nmol) prevented the depressor and sympathoinhibitory responses elicited by intracerebroventricular neuropeptide Y. Intravenous injection of the same dose of neuropeptide Y (1 nmol) as that used in the intracerebroventricular experiment failed to cause any cardiovascular and renal sympathetic nerve responses. On the other hand, a subdepressor dose of intracerebroventricular infusion of neuropeptide Y (1 nmol/300 µL per hour) significantly attenuated the baroreflex sensitivities assessed by renal sympathetic nerve activity and heart rate compared with vehicle infusion (G_max; -7.4±0.7 versus -13.7±0.9%/mm Hg, P<0.01, and -4.0±0.3 versus -6.7±0.8 bpm/mm Hg, P<0.05, respectively). These results suggest that central neuropeptide Y participates in the regulations of the sympathetic nerve activity to kidney and the baroreceptor reflex and that the depressor response induced by intracerebroventricular neuropeptide Y is modulated, at least in part, by central leptin in conscious rabbits.

Key Words: baroreceptors • central nervous system • neuropeptides • renal sympathetic nerve activity

This article has been cited by other articles:

				A. Barcelo, F. Barbe, E. Llompart, M. de la Pena, J. Duran-Cantolla, A. Ladaria, M. Bosch, L. Guerra, and A. G. N. Agusti Neuropeptide Y and Leptin in Patients with Obstructive Sleep Apnea Syndrome: Role of Obesity Am. J. Respir. Crit. Care Med., January 15, 2005; 171(2): 183 - 187. [Abstract] [Full Text] [PDF]

				Y. Lin, K. Matsumura, M. Fukuhara, S. Kagiyama, K. Fujii, and M. Iida Ghrelin Acts at the Nucleus of the Solitary Tract to Decrease Arterial Pressure in Rats Hypertension, May 1, 2004; 43(5): 977 - 982. [Abstract] [Full Text] [PDF]

				Z.-H. Zhang and R. B. Felder Melanocortin receptors mediate the excitatory effects of blood-borne murine leptin on hypothalamic paraventricular neurons in rat Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2004; 286(2): R303 - R310. [Abstract] [Full Text] [PDF]

				M. Michalkiewicz, K. M. Knestaut, E. Yu. Bytchkova, and T. Michalkiewicz Hypotension and Reduced Catecholamines in Neuropeptide Y Transgenic Rats Hypertension, May 1, 2003; 41(5): 1056 - 1062. [Abstract] [Full Text] [PDF]

				T. Shirasaka, M. Takasaki, and H. Kannan Cardiovascular effects of leptin and orexins Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2003; 284(3): R639 - R651. [Abstract] [Full Text] [PDF]

				K. Matsumura, T. Tsuchihashi, K. Fujii, I. Abe, and M. Iida Central Ghrelin Modulates Sympathetic Activity in Conscious Rabbits Hypertension, November 1, 2002; 40(5): 694 - 699. [Abstract] [Full Text] [PDF]

				S. J. Swoap Altered leptin signaling is sufficient, but not required, for hypotension associated with caloric restriction Am J Physiol Heart Circ Physiol, December 1, 2001; 281(6): H2473 - H2479. [Abstract] [Full Text] [PDF]

				K. Matsumura, T. Tsuchihashi, and I. Abe Central Human Cocaine- and Amphetamine-Regulated Transcript Peptide 55-102 Increases Arterial Pressure in Conscious Rabbits Hypertension, November 1, 2001; 38(5): 1096 - 1100. [Abstract] [Full Text] [PDF]

				K. Matsumura, T. Tsuchihashi, and I. Abe Central Orexin-A Augments Sympathoadrenal Outflow in Conscious Rabbits Hypertension, June 1, 2001; 37(6): 1382 - 1387. [Abstract] [Full Text] [PDF]