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(Hypertension. 2001;37:1060.)
© 2001 American Heart Association, Inc.

Hypothesis

Hypothesis

Pulse Pressure and Human Longevity

Abraham Aviv

From the Hypertension Research Center, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ.

Correspondence to Dr Abraham Aviv, Room F-464, MSB, Hypertension Research Center, 185 S Orange Ave, Newark, NJ 07103-2714. E-mail avivab{at}umdnj.edu

Abstract—In exploration of the association between pulse pressure and longevity in humans, 3 hypotheses are briefly discussed: the fetal origin hypothesis, antagonistic pleiotropy, and the telomere hypothesis of cellular aging. The implications of these hypotheses serve to draw a critical distinction between biologic age (aging) and chronological age and, thereby, offer an answer to a question that presently matters most in the field of hypertension: Why has it been so difficult to disentangle the genetic components of essential hypertension and to identify the variant genes responsible for elevated blood pressure in a large segment of the human population?

Key Words: aging • hypertension, essential • telomere • reactive oxygen species • menopause • evolution • genetics

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