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(Hypertension. 2001;37:1101.)
© 2001 American Heart Association, Inc.

Scientific Contributions

Fenestrations of the Carotid Internal Elastic Lamina and Structural Adaptation in Stroke-Prone Spontaneously Hypertensive Rats

Saliha Boumaza; Silvia M. Arribas; Mary Osborne-Pellegrin; John C. McGrath; Stéphane Laurent; Patrick Lacolley; Pascal Challande

From the "Institut National de la Santé et de la Recherche Médicale," INSERM U337 (S.B., S.L., P.L.) and U460 (M.O.-P.), Paris, France; Departamento de Fisiología, Facultad de Medicina, Universidad Autónoma de Madrid, Spain (S.M.A.); University of Glasgow, United Kingdom (J.C.M.); and Université Paris VI (P.C.), France.

Correspondence to Pascal Challande, MD, PhD, Laboratoire de Mécanique Physique, Université Pierre et Marie Curie, CNRS UPRESA 7068; 2 place de la gare de ceinture, F78210 Saint-Cyr l’Ecole, France. E-mail Challan{at}ccr.jussieu.fr

Abstract—Our aim was to determine the structural factors that determine the mechanical adaptation of the carotid arterial wall in stroke-prone hypertensive rats (SHRSP). Distensibility-pressure and elastic modulus–stress curves assessed by in vivo echo-tracking measurements indicated a reduction in arterial stiffness in 13-week-old SHRSP compared with Wistar-Kyoto rats (WKY). Elastin and collagen contents determined biochemically were not different between SHRSP and WKY. Confocal microscopy showed that the mean area of fenestrations and fraction of area occupied by fenestrations of the internal elastic lamina (IEL) were smaller in SHRSP than in WKY, which indicated a reduction in stress-concentration effects within the IEL. Immunohistologic staining of EIIIA fibronectin isoform and total fibronectin (also as determined by Western blot) was greater in SHRSP, which suggested increased cell-matrix interactions. We suggest that these structural modifications of the vascular wall play a synergistic role in the mechanical adaptation to a high level of stress in SHRSP.

Key Words: arteries • elastin • lamina, internal, elastic • fenestrations • fibronectin • remodeling • hypertension, experimental

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