(Hypertension. 2001;37:1273.)
© 2001 American Heart Association, Inc.
Scientific Contributions |
Effect of Antihypertensive Therapy on Renal Artery Structure in Type 2 Diabetic Rats With Hypertension
From the Department of Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark.
Correspondence to Alluru S. Reddi, MD, PhD, Department of Medicine, UMDNJ-New Jersey Medical School, 185 South Orange Ave, Newark, NJ 07103. E-mail reddias{at}umdnj.edu
Abstract—We
have previously demonstrated that antihypertensive treatment with
doxazosin (DZN), an 
-adrenergic blocker, and lisinopril
(LIS), an ACE inhibitor, reverse glomerular
sclerosis in corpulent spontaneously hypertensive rats with type 2
diabetes. In this study, we examined the effects of the above-mentioned
antihypertensive drugs alone and in combination on the structure of
interlobular and arcuate arteries in these rats. Both male and
female rats aged 6 months were treated with antihypertensive drugs for
16 weeks. Various structural parameters were evaluated by
light microscopy, with the use of digital image analysis, in
kidney sections stained with periodic acid–Schiff. Systolic
blood pressure was significantly lower in treated than in untreated
rats. Untreated diabetic rats had a significantly higher media/lumen
ratio (smaller luminal diameter) of both arteries compared with the
ratio in treated rats (for interlobular artery, 0.72±0.06 [no
treatment], 0.49±0.03 [DZN treatment], 0.54±0.06 [LIS
treatment], and 0.52±0.04 [combination therapy],
P<0.05 to <0.001 for
no treatment versus treatment; for arcuate artery, 0.66±0.11
[no treatment], 0.40±0.02 [DZN treatment], 0.39±0.04 [LIS
treatment], and 0.40±0.03 [combination therapy],
P<0.05 for no treatment versus
treatment). Antihypertensive treatment caused significant increases in
total arterial cross-sectional area, internal and external
diameters, luminal and medial cross-sectional area, and medial
thickness in both interlobular and arcuate arteries. The
improvement in arterial structure after antihypertensive
treatment was due to remodeling and growth of the vessels. Both DZN and
LIS were equally efficacious, and combination therapy had no additive
or synergistic
effect.
Key Words: kidney • arteries • hypertension, experimental • diabetes mellitus • rats, inbred SHR • adrenergic receptor blockers • angiotensin-converting enzyme inhibitors
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