This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Bengtsson, K. Articles by Groop, L. Search for Related Content PubMed PubMed Citation Articles by Bengtsson, K. Articles by Groop, L. Related Collections Other hypertension Type 2 diabetes Epidemiology Genetics of cardiovascular disease

(Hypertension. 2001;37:1303.)
© 2001 American Heart Association, Inc.

Scientific Contributions

ß₂-Adrenergic Receptor Gene Variation and Hypertension in Subjects With Type 2 Diabetes

Kristina Bengtsson; Marju Orho-Melander; Olle Melander; Ulf Lindblad; Jonas Ranstam; Lennart Råstam; Leif Groop

From the Department of Endocrinology (K.B, M.O.M., O.M., L.G.) and Department of Community Medicine (U.L. L.R.), Malmö University Hospital, Lund University, Malmö, Sweden; Billingen Health Care Center (K.B.), Skövde, Sweden; Skaraborg Institute (U.L.), Skövde, Sweden; and Malmö University (J.R.), Malmö, Sweden.

Correspondence and reprint requests to K. Bengtsson, MD, Billingen Health Care Center, Ekängsvägen 15, S-541 40 Skövde, Sweden. E-mail kristina.a.bengtsson{at}vgregion.se

Abstract—The aim of this study was to investigate whether polymorphisms in the ß₂-adrenergic receptor gene (5'LC-Arg19Cys, Arg16Gly, Gln27Glu) are associated with hypertension in patients with or without type 2 diabetes and with the blood pressure levels in normotensive sib pairs. The association study included 291 hypertensive patients without type 2 diabetes, 124 hypertensive patients with type 2 diabetes, and 265 healthy control subjects from Sweden. In addition, normotensive sib pairs that were discordant for the Arg16Gly (72 pairs) and Gln27Glu (40 pairs) polymorphisms were identified in type 2 diabetes families from Finland. Genotyping was performed using polymerase chain reaction–restriction fragment-length polymorphism analysis. Homozygous carriers of the Arg16 allele had a significantly increased odds ratio (OR) for hypertension in patients with type 2 diabetes (OR 2.14; 95% confidence interval [CI], 1.05 to 4.33), particularly among lean (body mass index<27 kg/m²) patients (OR 3.47; 95% CI, 1.06 to 11.33). The Gln27 allele showed a weaker association to hypertension (OR 1.55; 95% CI, 1.00 to 2.41) and was found to be in linkage disequilibrium with the Cys19 allele of the 5'LC-Arg19Cys polymorphism. In the paired-sibling analysis, siblings with at least 1 copy of the Arg16 allele had higher systolic blood pressure (P=0.049), and nondiabetic siblings had a higher body mass index (P=0.026) than siblings homozygous for the Gly16 allele. These results indicate that the Arg16 allele of the ß₂-adrenergic receptor gene confers an increased risk for hypertension in subjects with type 2 diabetes and is associated with higher blood pressure levels and higher body mass index in sib pairs who are discordant for the polymorphism.

Key Words: genetics • hypertension, genetic • blood pressure • diabetes • receptors, adrenergic, beta • sibling

This article has been cited by other articles:

				T. Lucas, D. Losert, M. Allen, J. Halaschek-Wiener, B. Pratscher, C. Friedrich, M. Wolschek, G. Fuchsjager-Mayrl, L. Schmetterer, H. Pehamberger, et al. Combination Allele-Specific Real-Time PCR for Differentiation of {beta}2-Adrenergic Receptor Coding Single-Nucleotide Polymorphisms Clin. Chem., April 1, 2004; 50(4): 769 - 772. [Full Text] [PDF]

				J. H. Eisenach, A. M. McGuire, R. M. Schwingler, S. T. Turner, and M. J. Joyner The Arg16/Gly {beta}2-adrenergic receptor polymorphism is associated with altered cardiovascular responses to isometric exercise Physiol Genomics, February 13, 2004; 16(3): 323 - 328. [Abstract] [Full Text] [PDF]

				J. Dallongeville, N. Helbecque, D. Cottel, P. Amouyel, and A. Meirhaeghe The Gly16->Arg16 and Gln27->Glu27 Polymorphisms of {beta}2-Adrenergic Receptor Are Associated with Metabolic Syndrome in Men J. Clin. Endocrinol. Metab., October 1, 2003; 88(10): 4862 - 4866. [Abstract] [Full Text] [PDF]

				M. Castellano, F. Rossi, M. Giacche, C. Perani, F. Rivadossi, M. L. Muiesan, M. Salvetti, M. Beschi, D. Rizzoni, and E. Agabiti-Rosei {beta}2-Adrenergic Receptor Gene Polymorphism, Age, and Cardiovascular Phenotypes Hypertension, February 1, 2003; 41(2): 361 - 367. [Abstract] [Full Text] [PDF]

				M. Tomaszewski, N. J.R. Brain, F. J. Charchar, W. Y.S. Wang, B. Lacka, S. Padmanabahn, J. S. Clark, N. H. Anderson, H. V. Edwards, E. Zukowska-Szczechowska, et al. Essential Hypertension and {beta}2-Adrenergic Receptor Gene: Linkage and Association Analysis Hypertension, September 1, 2002; 40(3): 286 - 291. [Abstract] [Full Text] [PDF]

				C. J. Ostgren, U. Lindblad, A. Melander, and L. Rastam Survival in Patients With Type 2 Diabetes in a Swedish Community: Skaraborg Hypertension and Diabetes Project Diabetes Care, August 1, 2002; 25(8): 1297 - 1302. [Abstract] [Full Text] [PDF]