(Hypertension. 2001;38:30.)
© 2001 American Heart Association, Inc.
Scientific Contributions |
Genomic Scan for Exercise Blood Pressure in the Health, Risk Factors, Exercise Training and Genetics (HERITAGE) Family Study
From the Pennington Biomedical Research Center, Human Genomics Laboratory (T. Rankinen, G.S., C.B.), Baton Rouge, La; the Division of Biostatistics (P.A., T. Rice, D.C.R.) and the Departments of Genetics and Psychiatry (D.C.R.), Washington University School of Medicine, St. Louis, Mo; the Physical Activity Sciences Laboratory (Y.C.C., J.G.) and the Laboratory of Molecular Endocrinology (J.G.), Laval University, Québec, Canada; the School of Kinesiology and Leisure Studies, University of Minnesota (A.S.L.), Minneapolis; the Department of Kinesiology, Indiana University (J.S.S.), Bloomington; and the Department of Health and Kinesiology, Texas A & M University (J.H.W.), College Station.
Correspondence to Dr Tuomo Rankinen, Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808-4124. E-mail rankint{at}pbrc.edu
Abstract— A genome-wide linkage scan was performed for genes affecting submaximal exercise systolic blood pressure (SBP) and diastolic blood pressure (DBP) in the sedentary state and their responses to a standardized endurance training program. A total of 344 polymorphic markers were used, and 344 pairs of siblings from 99 white nuclear families and 102 sibling pairs from 105 black family units were available for the study. All subjects were healthy but sedentary at baseline. SBP and DBP were measured during exercise tests at 2 different intensities: 50 W (SBP50 and DBP50) and 80% of maximal oxygen consumption (SBP80 and DBP80). Baseline blood pressure phenotypes were adjusted for age, gender, and body mass index, and the training responses (after training minus baseline [
]) were adjusted for age, gender, baseline body mass index, and baseline blood pressure. Two analytical strategies were used: a multipoint variance-components linkage analysis using all the family data and a single-point linkage analysis using pairs of siblings. In whites, promising linkages (lod score >1.75) were detected for baseline SBP80 on 10q23-q24 and for SBP50 on 8q21. In addition, several chromosomal regions with suggestive evidence of linkage (lod score 1.0 to 1.75) were observed for SBP50 (22q11.2-q13), DBP50 (6q23-q27), SBP80 (2p24, 2q21, 14q11.1-q12, and 16q21), DBP80 (6q13-q21), SBP50 (7p12-p13), and DBP50 (5q31-q32). In blacks, DBP50, DBP80, and DBP80 showed promising quantitative trait loci on 18p11.2, 11q13-q21, and 10q21-q23, respectively. Suggestive linkages were evident for DBP50 on 2p22-p25, 11p15.5, and 18q21.1; for SBP80 on 6q21-q21, 6q31-q36, 12q12-q13, 15q12-q13, and 17q11-q12; and for DBP80 on 8q24, 10q21-q24, and 12p13. All the detected chromosomal regions include several potential candidate genes and therefore warrant further studies in the Health, Risk Factors, Exercise Training and Genetics (HERITAGE) cohort and other studies.
Key Words: genes • blood pressure • exercise • linkage
Related Article:
Hypertension 2001 38: 38-40.
This article has been cited by other articles:
 |
|
 |
|
  R. S. Vasan, N. L. Glazer, J. F. Felix, W. Lieb, P. S. Wild, S. B Felix, N. Watzinger, M. G. Larson, N. L. Smith, A. Dehghan, et al. Genetic Variants Associated With Cardiac Structure and Function: A Meta-analysis and Replication of Genome-wide Association Data JAMA, July 8, 2009; 302(2): 168 - 178. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Lippi, U. G. Longo, and N. Maffulli Genetics and sports Br. Med. Bull., February 9, 2009; (2009) ldp007v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Spielmann, A. S. Leon, D. C. Rao, T. Rice, J. S. Skinner, T. Rankinen, and C. Bouchard Genome-wide linkage scan for submaximal exercise heart rate in the HERITAGE family study Am J Physiol Heart Circ Physiol, December 1, 2007; 293(6): H3366 - H3371. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Tomaszewski, F. J. Charchar, M. D. Lynch, S. Padmanabhan, W. Y.S. Wang, W. H. Miller, W. Grzeszczak, C. Maric, E. Zukowska-Szczechowska, and A. F. Dominiczak Fibroblast Growth Factor 1 Gene and Hypertension: From the Quantitative Trait Locus to Positional Analysis Circulation, October 23, 2007; 116(17): 1915 - 1924. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Ingelsson, M. G. Larson, R. S. Vasan, C. J. O'Donnell, X. Yin, J. N. Hirschhorn, C. Newton-Cheh, J. A. Drake, S. L. Musone, N. L. Heard-Costa, et al. Heritability, Linkage, and Genetic Associations of Exercise Treadmill Test Responses Circulation, June 12, 2007; 115(23): 2917 - 2924. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Pojoga, N. S. Kolatkar, J. S. Williams, T. S. Perlstein, X. Jeunemaitre, N. J. Brown, P. N. Hopkins, B. A. Raby, and G. H. Williams {beta}-2 Adrenergic Receptor Diplotype Defines a Subset of Salt-Sensitive Hypertension Hypertension, November 1, 2006; 48(5): 892 - 900. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. S. Farooqi, S. Drop, A. Clements, J. M. Keogh, J. Biernacka, S. Lowenbein, B. G. Challis, and S. O'Rahilly Heterozygosity for a POMC-Null Mutation and Increased Obesity Risk in Humans Diabetes, September 1, 2006; 55(9): 2549 - 2553. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Pausova, D. Gaudet, F. Gossard, M. Bernard, M. L. Kaldunski, M. Jomphe, J. Tremblay, T. J. Hudson, G. Bouchard, T. A. Kotchen, et al. Genome-Wide Scan for Linkage to Obesity-Associated Hypertension in French Canadians Hypertension, December 1, 2005; 46(6): 1280 - 1285. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Cai, S. A Cole, R. A Bastarrachea-Sosa, J. W MacCluer, J. Blangero, and A. G Comuzzie Quantitative trait locus determining dietary macronutrient intakes is located on human chromosome 2p22 Am. J. Clinical Nutrition, November 1, 2004; 80(5): 1410 - 1414. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. J. F. Loos, P. T. Katzmarzyk, D. C. Rao, T. Rice, A. S. Leon, J. S. Skinner, J. H. Wilmore, T. Rankinen, and C. Bouchard Genome-Wide Linkage Scan for the Metabolic Syndrome in the HERITAGE Family Study J. Clin. Endocrinol. Metab., December 1, 2003; 88(12): 5935 - 5943. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. J. Camp, P. N. Hopkins, S. J. Hasstedt, H. Coon, A. Malhotra, R. M. Cawthon, and S. C. Hunt Genome-Wide Multipoint Parametric Linkage Analysis of Pulse Pressure in Large, Extended Utah Pedigrees Hypertension, September 1, 2003; 42(3): 322 - 328. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Kotchen, U. Broeckel, C. E. Grim, P. Hamet, H. Jacob, M. L. Kaldunski, J. M. Kotchen, N. J. Schork, P. J. Tonellato, and A. W. Cowley Jr Identification of Hypertension-Related QTLs in African American Sib Pairs Hypertension, November 1, 2002; 40(5): 634 - 639. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Tomaszewski, N. J.R. Brain, F. J. Charchar, W. Y.S. Wang, B. Lacka, S. Padmanabahn, J. S. Clark, N. H. Anderson, H. V. Edwards, E. Zukowska-Szczechowska, et al. Essential Hypertension and {beta}2-Adrenergic Receptor Gene: Linkage and Association Analysis Hypertension, September 1, 2002; 40(3): 286 - 291. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Rankinen, P. An, L. Perusse, T. Rice, Y. C. Chagnon, J. Gagnon, A. S. Leon, J. S. Skinner, J. H. Wilmore, D. C. Rao, et al. Genome-wide linkage scan for exercise stroke volume and cardiac output in the HERITAGE Family Study Physiol Genomics, August 14, 2002; 10(2): 57 - 62. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. C. Hunt, R. C. Ellison, L. D. Atwood, J. S. Pankow, M. A. Province, and M. F. Leppert Genome Scans for Blood Pressure and Hypertension: The National Heart, Lung, and Blood Institute Family Heart Study Hypertension, July 1, 2002; 40(1): 1 - 6. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. O. Lim and T. Rankinen Role of Aldosterone in the Pathogenesis of Hypertension * Response Hypertension, February 1, 2002; 39 (2): e14 - e14. [Full Text] [PDF]
|
|
|
|
|
|
F. C. Luft and A. Busjahn Peaks and Valleys Hypertension, July 1, 2001; 38(1): 38 - 40. [Full Text] [PDF]
|
|