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(Hypertension. 2001;38:222.)
© 2001 American Heart Association, Inc.

Scientific Contributions

Aerobic Exercise Training Does Not Modify Large-Artery Compliance in Isolated Systolic Hypertension

Kathryn E. Ferrier; Tamara K. Waddell; Christoph D. Gatzka; James D. Cameron; Anthony M. Dart; Bronwyn A. Kingwell

From the Alfred and Baker Medical Unit, Baker Medical Research Institute, Melbourne, Australia.

Correspondence to Dr Bronwyn Kingwell, Alfred and Baker Medical Unit, Baker Medical Research Institute, PO Box 6492, St Kilda Rd Central, Melbourne 8008, Australia. E-mail b.kingwell{at}alfred.org.au

Abstract—— The present study characterized large-artery properties in patients with isolated systolic hypertension (ISH) and determined the efficacy of exercise training in modifying these properties. Twenty patients (10 male and 10 female) with stage I ISH and 20 age- and gender-matched control subjects were recruited, and large-artery properties were assessed noninvasively. Ten ISH patients (5 male and 5 female) were enrolled in a randomized crossover study comparing 8 weeks of moderate intensity cycling with 8 weeks of sedentary activity. Brachial and carotid systolic, diastolic, mean, and pulse pressures were higher in the ISH group than in the control group. Systemic arterial compliance (0.43±0.04 versus 0.29±0.02 arbitrary compliance units for the control versus ISH groups, respectively; P=0.01) was lower, and carotid-to-femoral pulse-wave velocity (9.67±0.36 versus 11.43±0.51 m · s^-1 for the control versus ISH groups, respectively; P=0.007), input impedance (2.39±0.19 versus 3.27±0.34 mm Hg · s · cm^-1 for the control versus ISH groups, respectively; P=0.04), and characteristic impedance (1.67±0.17 versus 2.34±0.27 mm Hg · s · cm^-1 for the control versus ISH groups, respectively; P=0.05) were higher in the ISH group than in the control group. Training increased maximal oxygen consumption by 13±5% (P=0.04) and maximum workload by 8±4% (P=0.05); however, there was no effect on arterial mechanical properties, blood lipids, or left ventricular mass or function. These results suggest that the large-artery stiffening associated with ISH is resistant to modification through short-term aerobic training.

Key Words: hypertension, isolated systolic • arteries • compliance • exercise • aorta

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