This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Correia, M. L.G. Articles by Haynes, W. G. Search for Related Content PubMed PubMed Citation Articles by Correia, M. L.G. Articles by Haynes, W. G. Related Collections Obesity Animal models of human disease Hypertension - basic studies Autonomic, reflex, and neurohumoral control of circulation

(Hypertension. 2001;38:384.)
© 2001 American Heart Association, Inc.

Scientific Contributions

Role of Corticotrophin-Releasing Factor in Effects of Leptin on Sympathetic Nerve Activity and Arterial Pressure

Marcelo L.G. Correia; Donald A. Morgan; Jennifer L. Mitchell; William I. Sivitz; Allyn L. Mark; William G. Haynes

Specialized Center of Research in Hypertension Genetics, Department of Internal Medicine, University of Iowa, and Veterans Affairs Medical Center, Iowa City, Iowa.

Correspondence to William G. Haynes, MD, Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, IA 52242. E-mail william-g-haynes{at}uiowa.edu

Abstract—— Leptin and corticotrophin-releasing factor increase sympathetic nervous activity to interscapular brown adipose tissue, kidneys, and adrenal glands. Leptin is known to increase hypothalamic corticotrophin-releasing factor. In this study, we tested the hypothesis that leptin-dependent increases in sympathetic nervous activity are mediated through increases in central nervous system corticotrophin-releasing factor activity. We examined the effects of intracerebroventricular administration of corticotrophin-releasing factor and intravenous leptin on sympathetic nervous activity to interscapular brown adipose tissue through multifiber neurography in anesthetized Sprague-Dawley rats pretreated with intracerebroventricular -helical corticotrophin-releasing factor_9–41 (corticotrophin-releasing factor receptor antagonist) or vehicle. Centrally administered corticotrophin-releasing factor substantially increased interscapular brown adipose tissue sympathetic nervous activity. The responses to corticotrophin-releasing factor were substantially attenuated in animals pretreated with -helical corticotrophin-releasing factor_9–41. Leptin-dependent increases in interscapular brown adipose tissue sympathetic nervous activity were significantly inhibited by pretreatment with -helical corticotrophin-releasing factor_9–41. Interestingly, leptin also significantly increased arterial pressure over 6 hours, but this pressor action was not attenuated by the corticotrophin-releasing factor receptor antagonist. These results suggest that corticotrophin-releasing factor may mediate the sympathoexcitatory effect of leptin on thermogenic tissue without altering its cardiovascular actions.

Key Words: arteries • blood pressure • leptin • sympathetic nervous system • metabolism

This article has been cited by other articles:

				K. K. Koh, S. M. Park, and M. J. Quon Leptin and Cardiovascular Disease: Response to Therapeutic Interventions Circulation, June 24, 2008; 117(25): 3238 - 3249. [Full Text] [PDF]

				W. G Haynes Role of leptin in obesity-related hypertension Exp Physiol, September 1, 2005; 90(5): 683 - 688. [Abstract] [Full Text] [PDF]

				K. Rahmouni and W. G. Haynes Leptin and the Cardiovascular System Recent Prog. Horm. Res., January 1, 2004; 59(1): 225 - 244. [Abstract] [Full Text]

				B. CANNON and J. NEDERGAARD Brown Adipose Tissue: Function and Physiological Significance Physiol Rev, January 1, 2004; 84(1): 277 - 359. [Abstract] [Full Text] [PDF]

				A. J. Marsh, M. A.P. Fontes, S. Killinger, D. B. Pawlak, J. W. Polson, and R. A.L. Dampney Cardiovascular Responses Evoked by Leptin Acting on Neurons in the Ventromedial and Dorsomedial Hypothalamus Hypertension, October 1, 2003; 42(4): 488 - 493. [Abstract] [Full Text] [PDF]

				K. Rahmouni, W. G. Haynes, D. A. Morgan, and A. L. Mark Role of Melanocortin-4 Receptors in Mediating Renal Sympathoactivation to Leptin and Insulin J. Neurosci., July 9, 2003; 23(14): 5998 - 6004. [Abstract] [Full Text] [PDF]

				T. E. Lohmeier, S. Warren, and J. T. Cunningham Sustained Activation of the Central Baroreceptor Pathway in Obesity Hypertension Hypertension, July 1, 2003; 42(1): 96 - 102. [Abstract] [Full Text] [PDF]

				J. Y. Jeon, V. J. Harber, and R. D. Steadward Leptin response to short-term fasting in sympathectomized men: role of the SNS Am J Physiol Endocrinol Metab, March 1, 2003; 284(3): E634 - E640. [Abstract] [Full Text] [PDF]

				J. Y. Jeon, R. D. Steadward, G. D. Wheeler, G. Bell, L. McCargar, and V. Harber Intact Sympathetic Nervous System Is Required for Leptin Effects on Resting Metabolic Rate in People with Spinal Cord Injury J. Clin. Endocrinol. Metab., January 1, 2003; 88(1): 402 - 407. [Abstract] [Full Text] [PDF]