Hypertension, Vol 4, 681-685, Copyright © 1982 by American Heart Association
D Susic, AK Mandal and D Kentera
This study describes the effect of heparin on blood pressure, cardiac
output, and total peripheral resistance in spontaneously hypertensive and
one-kidney, one clip Goldblatt hypertensive rats. Administration of heparin
(200 units/day/rat) for 8 weeks to young (6-week-old) spontaneously
hypertensive rats (SHR) resulted in an attenuated rise in blood pressure;
mean blood pressure in heparin-treated SHR (180 +/- mm Hg) was
significantly lower (p less than 0.05) than that in control SHR (205 +/- 7
mm Hg). Similar heparin treatment started immediately after the induction
of one-kidney, one clip (Goldblatt) hypertension reduced the rise in blood
pressure. After 4 weeks of treatment, heparin-treated Goldblatt
hypertensive rats had much lower blood pressure (150 +/- 4 mm Hg) than did
control rats (7178 +/- 8 mm Hg). The difference was highly significant (p
less than 0.01). Similarly, heparin treatment also lowered the blood
pressure in rats with developed Goldblatt hypertension. After the cessation
of heparin treatment, the blood pressure returned to pretreatment level in
these rats. When compared to vehicle-treated rats, heparin-treated animals
with either spontaneous or Goldblatt hypertension concomitantly exhibited a
significant increase in cardiac output, and significant decreases in total
peripheral resistance and packed cell volume. Further, the left ventricular
weight to body weight ratio was significantly lower (p less than 0.05) in
heparin-treated than control animals. Since a relationship seems to exist
between an increase in packed cell volume and blood viscosity and the rise
in arterial pressure, this blood- pressure-lowering effect of heparin may
be attributed to a decrease in packed cell volume.
ARTICLES
Heparin lowers the blood pressure in hypertensive rats
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