Published online before print October 21, 2002, doi: 10.1161/01.HYP.0000038339.67450.60
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
(Hypertension. 2002;40:797.)
© 2002 American Heart Association, Inc.
Scientific Contributions |
Lack of Long-Term Effect of Vitamin C Supplementation on Blood Pressure
From the Epidemiology and Biostatistics Division, National Cancer Center Research Institute East (M.K.K., S.S., S.S., S.T.), Kashiwa, Japan; and Hiraka General Hospital (S.O., M.H.), Yokote, Japan.
Correspondence to Dr S. Tsugane, Epidemiology and Biostatistics Division, National Cancer Center Research Institute East, 6-5-1 Kashiwanoha, Kashiwa City, Chiba 277-8577, Japan. E-mail stsugane{at}east.ncc.go.jp
In a double-blinded randomized controlled trial, we investigated the long-term effect of vitamin C supplementation on blood pressure. A total of 439 Japanese subjects with atrophic gastritis initially participated in the trial using vitamin C and ß-carotene to prevent gastric cancer. Before and on early termination of ß-carotene supplementation, 134 subjects dropped out of this trial, whereas 120 and 124 subjects took the vitamin C supplement daily at either 50 mg or 500 mg, respectively, for 5 years. Before supplementation, neither systolic nor diastolic blood pressure was significantly related with the serum vitamin C concentration. This relationship was unchanged after adjustment for age, body mass index, and alcohol intake or after stratification by gender. After 5 years, systolic blood pressure significantly increased in groups, regardless of vitamin C dose, compared with baseline. Systolic blood pressure in the high-dose group (500 mg daily) increased from 125.4 to 131.7 mm Hg (5.88 mm Hg increase; 95% confidence interval [CI], 3.11 to 8.65). This value was similar with that of the low-dose group (5.73 mm Hg increase; 95% CI, 2.62 to 8.83) and of the dropout group (4.52 mm Hg increase; 95% CI, 1.26 to 7.77). There was no difference in change of diastolic blood pressure among the 3 groups. In conclusion, we observed no reduction in blood pressure with long-term moderate doses (500 mg/day) of vitamin C supplementation in a high-risk population for stomach cancer and stroke.
Key Words: vitamins • blood pressure • antihypertensive agents • clinical trials
This article has been cited by other articles:
 |
|
 |
|
  C. Vecchione, D. Carnevale, A. Di Pardo, M. T. Gentile, A. Damato, G. Cocozza, G. Antenucci, G. Mascio, U. Bettarini, A. Landolfi, et al. Pressure-Induced Vascular Oxidative Stress Is Mediated Through Activation of Integrin-Linked Kinase 1/{beta}PIX/Rac-1 Pathway Hypertension, November 1, 2009; 54(5): 1028 - 1034. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Lopez-Ruiz, J. Sartori-Valinotti, L. L. Yanes, R. Iliescu, and J. F. Reckelhoff Sex differences in control of blood pressure: role of oxidative stress in hypertension in females Am J Physiol Heart Circ Physiol, August 1, 2008; 295(2): H466 - H474. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Grossman Does Increased Oxidative Stress Cause Hypertension? Diabetes Care, February 1, 2008; 31(Supplement_2): S185 - S189. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. J. Appel, M. W. Brands, S. R. Daniels, N. Karanja, P. J. Elmer, and F. M. Sacks Dietary Approaches to Prevent and Treat Hypertension: A Scientific Statement From the American Heart Association Hypertension, February 1, 2006; 47(2): 296 - 308. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Chen, R. J. Karne, G. Hall, U. Campia, J. A. Panza, R. O. Cannon III, Y. Wang, A. Katz, M. Levine, and M. J. Quon High-dose oral vitamin C partially replenishes vitamin C levels in patients with Type 2 diabetes and low vitamin C levels but does not improve endothelial dysfunction or insulin resistance Am J Physiol Heart Circ Physiol, January 1, 2006; 290(1): H137 - H145. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. A. Fortepiani and J. F. Reckelhoff Increasing oxidative stress with molsidomine increases blood pressure in genetically hypertensive rats but not normotensive controls Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2005; 289(3): R763 - R770. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. R. Chade, M. Rodriguez-Porcel, J. Herrmann, X. Zhu, J. P. Grande, C. Napoli, A. Lerman, and L. O. Lerman Antioxidant Intervention Blunts Renal Injury in Experimental Renovascular Disease J. Am. Soc. Nephrol., April 1, 2004; 15(4): 958 - 966. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Rodriguez-Iturbe, N. D. Vaziri, J. Herrera-Acosta, and R. J. Johnson Oxidative stress, renal infiltration of immune cells, and salt-sensitive hypertension: all for one and one for all Am J Physiol Renal Physiol, April 1, 2004; 286(4): F606 - F616. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. R. Chade, M. Rodriguez-Porcel, J. Herrmann, J. D. Krier, X. Zhu, A. Lerman, and L. O. Lerman Beneficial Effects of Antioxidant Vitamins on the Stenotic Kidney Hypertension, October 1, 2003; 42(4): 605 - 612. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. J Hoggatt Commentary: Vitamin supplement use and confounding by lifestyle Int. J. Epidemiol., August 1, 2003; 32(4): 553 - 555. [Full Text] [PDF]
|
|
|
|
 |
|
 Minerva BMJ, January 11, 2003; 326(7380): 112 - 112. [Full Text] [PDF]
|
|
|
|
|
|
L. P. Svetkey and C. M. Loria Blood Pressure Effects of Vitamin C: What's the Key Question? Hypertension, December 1, 2002; 40(6): 789 - 791. [Full Text] [PDF]
|
|