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(Hypertension. 2003;41:75.)
© 2003 American Heart Association, Inc.

Scientific Contributions

Echocardiographic Wall Motion Abnormalities in Hypertensive Patients With Electrocardiographic Left Ventricular Hypertrophy

The LIFE Study

Vittorio Palmieri; Peter M. Okin; Jonathan N. Bella; Eva Gerdts; Kristian Wachtell; Julius Gardin; Vasilios Papademetriou; Markku S. Nieminen; Björn Dahlöf; Richard B. Devereux

From the Cornell Medical Center (V.P., P.M.O., J.N.B., R.B.D.), New York, New York; Haukeland Hospital (E.G.), Bergen, Norway; Copenhagen County University Hospital (K.W.), Glostrup, Denmark; St. John Hospital and Medical Center (J.G.), Detroit, Michigan; Veteran Affairs Medical Center (V.P.), Washington, DC; Helsinki University Central Hospital (M.S.N.), Helsinki, Finland; Sahlgrenska University Hospital-Östra (B.D.), Göteborg, Sweden.

Correspondence to Vittorio Palmieri, MD, Federico II University Hospital of Naples, Department of Clinical and Experimental Medicine, via Pansini 5 (Ed. 1), Naples, Italy. E-mail: vpalmier{at}med.cornell.eduAddress for reprints: Richard B Devereux, MD, Weill Medical College of Cornell University, 525 East 68th Street, New York, NY, 10021. E-mail rbdevere@med.cornell.edu

There is limited information on correlates of left ventricular wall motion (WM) abnormalities in ambulatory patients with hypertension and ECG left ventricular hypertrophy by Cornell voltage-duration product and/or Sokolow-Lyon voltage criteria. Therefore, we assessed the prevalence and the correlates of echocardiographic global and segmental left ventricular WM abnormalities in 942 hypertensive patients with hypertrophy enrolled in the Losartan Intervention For End-point reduction in hypertension (LIFE) echo substudy. Patients were separated into groups of those with normal WM or those with segmental or global WM abnormalities. Segmental and global WM abnormalities were mostly of mild degree and were detected in 7% and 6% of the study sample. Compared with subjects with normal motion, those with WM abnormalities were mostly men and had higher prevalences of self-reported coronary heart disease, ECG signs of myocardial infarction, ST-strain pattern, and higher Cornell voltage-duration product, echo-left ventricular mass, and albuminuria, but lower total and high-density lipoprotein cholesterol. Blood pressure was similar among groups. No significant differences were found between patients with global or segmental WM abnormalities. Only half of patients with WM abnormalities had a history or ECG signs of coronary heart disease. Independent correlates of WM abnormalities were higher albuminuria and Cornell voltage-duration product, male gender, and echo-left ventricular hypertrophy, but lower cholesterol. In a subanalysis restricted to patients with WM abnormalities, those with evident cardiovascular disease had a higher prevalence of ST-strain pattern than those with subclinical WM abnormalities, but other clinical, ECG, or echocardiographic parameters were indistinguishable between the 2 groups. Thus, in hypertensives with ECG left ventricular hypertrophy, WM abnormalities, mostly of mild degree, occurred in one eighth of the patients and were associated with male gender, left ventricular hypertrophy, and albuminuria. No significant differences were found between patients with global or segmental wall motion abnormalities.

Key Words: hypertension, arterial • echocardiography • hypertrophy • ventricular function, left • coronary heart disease • risk factors

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