This Article Full Text Full Text (PDF) All Versions of this Article: 41/3/488    most recent 01.HYP.0000056525.17476.D7v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Angeli, F. Articles by Bentivoglio, M. Search for Related Content PubMed PubMed Citation Articles by Angeli, F. Articles by Bentivoglio, M. Pubmed/NCBI databases Medline Plus Health Information High Blood Pressure Related Collections Other hypertension Hypertrophy Clinical Studies

(Hypertension. 2003;41:488.)
© 2003 American Heart Association, Inc.

Scientific Contributions

Association Between Periodontal Disease and Left Ventricle Mass in Essential Hypertension

Fabio Angeli; Paolo Verdecchia; Concetta Pellegrino; Rosaria Giulia Pellegrino; Giacinto Pellegrino; Lucio Prosciutti; Claudia Giannoni; Stefano Cianetti; Maurizio Bentivoglio

From Dipartimento Malattie Cardiovascolari, Università degli Studi di Perugia and Ospedale R. Silvestrini (F.A., P.V., L.P., M.B.), Perugia; and Università degli Studi di Perugia, Corso di Laurea in Odontoiatria e Protesi Dentaria (C.P., R.G.P., G.P., C.G., S.C.), Perugia, Italy.

Correspondence to Fabio Angeli, MD, Via Eugubina n. 68 A/8, 06100 Perugia, Italy. E-mail fangeli{at}cardionet.it

Chronic periodontitis has been associated with an increased risk for cardiovascular disease. Left ventricular mass is an established independent predictor of cardiovascular disease. In the present cross-sectional study, we tested the association between periodontitis and left ventricular mass in subjects with essential hypertension. One hundred four untreated subjects with essential hypertension underwent clinical examinations, including echocardiographic study, laboratory tests, and assessment of periodontal status according to the community periodontal index of treatment needs (CPITN). With increasing severity of periodontitis, there was a progressive increase in left ventricle mass. Mean values (g/height^2.7) were 39.0 (±2.7) in CPITN 0 (periodontal health), 40.2 (±6.4) in CPITN 1 (gingival bleeding), 42.7 (±6.8) in CPITN 2 (calculus), 51.4 (±11.7) in CPITN 3 (pockets 4 to 5 mm), and 76.7 (±11.3) in CPITN 4 (pockets 6 mm) (overall F 51.2; P<0.0001). Body surface area (P=0.04), systolic (P<0.0001) and diastolic (P<0.01) blood pressure, and left ventricular mass (P<0.0001) were determinants of a composite of CPITN 3 and 4. In a multivariate logistic analysis, left ventricular mass was the sole determinant (P<0.0001) of CPITN stages 3 and 4. Our findings suggest a direct association between severity of periodontitis and left ventricular mass in subjects with essential hypertension. Periodontal evaluation might contribute to refine cardiovascular risk assessment in hypertensive subjects.

Key Words: hypertension, essential • left ventricular hypertrophy • periodontal disease • left ventricular mass • echocardiography

This article has been cited by other articles:

				F. D'Aiuto, W. Sabbah, G. Netuveli, N. Donos, A. D. Hingorani, J. Deanfield, and G. Tsakos Association of the Metabolic Syndrome with Severe Periodontitis in a Large U.S. Population-Based Survey J. Clin. Endocrinol. Metab., October 1, 2008; 93(10): 3989 - 3994. [Abstract] [Full Text] [PDF]

				A. Spahr, E. Klein, N. Khuseyinova, C. Boeckh, R. Muche, M. Kunze, D. Rothenbacher, G. Pezeshki, A. Hoffmeister, and W. Koenig Periodontal Infections and Coronary Heart Disease: Role of Periodontal Bacteria and Importance of Total Pathogen Burden in the Coronary Event and Periodontal Disease (CORODONT) Study. Arch Intern Med, March 13, 2006; 166(5): 554 - 559. [Abstract] [Full Text] [PDF]

				J. H. Meurman, M. Sanz, and S.-J. Janket ORAL HEALTH, ATHEROSCLEROSIS, AND CARDIOVASCULAR DISEASE Critical Reviews in Oral Biology & Medicine, November 1, 2004; 15(6): 403 - 413. [Abstract] [Full Text] [PDF]

				A. Taguchi, M. Sanada, Y. Suei, M. Ohtsuka, K. Lee, K. Tanimoto, M. Tsuda, K. Ohama, M. Yoshizumi, and Y. Higashi Tooth Loss Is Associated With an Increased Risk of Hypertension in Postmenopausal Women Hypertension, June 1, 2004; 43(6): 1297 - 1300. [Abstract] [Full Text] [PDF]