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(Hypertension. 2003;41:1228.)
© 2003 American Heart Association, Inc.

Scientific Contributions

Adolescent Pain Sensitivity Is Associated With Cardiac Autonomic Function and Blood Pressure Over 8 Years

Tavis S. Campbell; Blaine Ditto; Jean R. Séguin; Sarah Sinray; Richard E. Tremblay

From the Department of Psychology, McGill University (T.S.C., B.D., S.S.), Montreal, Canada; and the Research Unit on Psychosocial Maladjustment, University of Montreal (J.R.S., R.E.T.), Montreal, Canada.

Correspondence to Blaine Ditto, PhD, Department of Psychology, McGill University, 1205 Dr Penfield Ave, Montreal, Quebec, H3A 1B1, Canada. E-mail blaine{at}hebb.psych.mcgill.ca

Low pain sensitivity has been reported in hypertensive subjects as well in groups deemed to be at increased risk of development of the disorder. However, it is uncertain whether individual differences in pain sensitivity are associated prospectively with increases in blood pressure. In the current study, 24-hour blood pressure and heart rate variability were recorded in 110, 22-year-old men previously assessed at age 14 years for casual blood pressure and pain sensitivity (mechanical finger pressure). Significant correlations were observed between pain tolerance in 14-year-olds and current 24-hour systolic blood pressure (r=0.37, P<0.01) and diastolic blood pressure (r=0.36, P<0.01). Hierarchical multiple regression analyses indicated that information regarding pain tolerance improved prediction of systolic and diastolic blood pressure at age 22 years beyond that afforded by differences in blood pressure, parental history of hypertension, and body mass index at age 14 years. Similar analyses revealed that average pain sensitivity at age 14 was also associated with 24-hour high-frequency heart rate variability (r=0.28, P<0.01) and low-frequency/high-frequency heart rate variability at age 22 (r=-0.35, P<0.01), suggesting increased sympathetic and reduced parasympathetic tone among individuals less sensitive to pain. These results provide further evidence that blood pressure related hypoalgesia might be related to processes involved in blood pressure regulation as well as in the development of sustained high blood pressure.

Key Words: adolescence • blood pressure • autonomic nervous system • risk factors • prospective studies

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