Hypertension. 2003;42:231-234
Published online before print July 14, 2003, doi: 10.1161/01.HYP.0000083488.67550.B8
Published online before print July 14, 2003, doi: 10.1161/01.HYP.0000083488.67550.B8
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
(Hypertension. 2003;42:231.)
© 2003 American Heart Association, Inc.
Rapid Communications |
Association of Hypoadiponectinemia With Impaired Vasoreactivity
From the Departments of Internal Medicine and Molecular Science (N.O., S.K., T.F., T.N., H.N., M. Kumada, K.O., Y.O., H.N., K.K., N.M., A.N., H.K., H.H., Y.M.) and Geriatric Medicine (M.O., N.K., M. Kaibe, H.R., T.O.), Graduate School of Medicine, Osaka University, Osaka, Japan.
Correspondence to Shinji Kihara, MD, PhD, Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, 2-2, Yamada-Oka, Suita, 565-0671 Osaka, Japan. E-mail kihara{at}imed2.med.osaka-u.ac.jp
Endothelial dysfunction is a crucial feature in the evolution of atherosclerosis. Adiponectin is an adipocyte-specific plasma protein with antiatherogenic and antidiabetic properties. In the present study, we investigated the relation between adiponectin and endothelium-dependent vasodilation. We analyzed endothelial function in 202 hypertensive patients, including those who were not taking any medication. Forearm blood flow was measured by strain-gauge plethysmography. Plasma adiponectin level was highly correlated with the vasodilator response to reactive hyperemia in the total (r=0.257, P<0.001) and no-medication (r=0.296, P=0.026) groups but not with nitroglycerin-induced hyperemia, indicating that adiponectin affected endothelium-dependent vasodilation. Multiple regression analysis of data from all hypertensive patients revealed that plasma adiponectin level was independently correlated with the vasodilator response to reactive hyperemia. Vascular reactivity was also analyzed in aortic rings from adiponectin-knockout (KO) and wild-type (WT) mice. Adiponectin-KO mice showed obesity, hyperglycemia, and hypertension compared with WT mice after 4 weeks on an atherogenic diet. Endothelium-dependent vasodilation in response to acetylcholine was significantly reduced in adiponectin-KO mice compared with WT mice, although no significant difference was observed in endothelium-independent vasodilation in response to sodium nitroprusside. Our observations suggest that hypoadiponectinemia is associated with impaired endothelium-dependent vasorelaxation and that the measurement of plasma adiponectin level might be helpful as a marker of endothelial dysfunction.
Key Words: endothelium • hypertension, essential • acetylcholine • adipose tissue • atherosclerosis
This article has been cited by other articles:
 |
|
 |
|
  B. Chandrasekar, W. H. Boylston, K. Venkatachalam, N. J. G. Webster, S. D. Prabhu, and A. J. Valente Adiponectin Blocks Interleukin-18-mediated Endothelial Cell Death via APPL1-dependent AMP-activated Protein Kinase (AMPK) Activation and IKK/NF-{kappa}B/PTEN Suppression J. Biol. Chem., September 5, 2008; 283(36): 24889 - 24898. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Malyszko, J.S. Malyszko, P. Kozminski, K. Pawlak, and M. Mysliwiec Adipokines, Linking Adipocytes and Vascular Function in Hemodialyzed Patients, May Also Be Possibly Related to CD146, a Novel Adhesion Molecule Clinical and Applied Thrombosis/Hemostasis, July 1, 2008; 14(3): 338 - 345. [Abstract] [PDF]
|
|
|
|
 |
|
 S.-Q. Xu, K. Mahadev, X. Wu, L. Fuchsel, S. Donnelly, R. G. Scalia, and B. J. Goldstein Adiponectin Protects Against Angiotensin II or Tumor Necrosis Factor {alpha}-Induced Endothelial Cell Monolayer Hyperpermeability: Role of cAMP/PKA Signaling Arterioscler. Thromb. Vasc. Biol., May 1, 2008; 28(5): 899 - 905. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. T. Gonon, U. Widegren, A. Bulhak, F. Salehzadeh, J. Persson, P.-O. Sjoquist, and J. Pernow Adiponectin protects against myocardial ischaemia-reperfusion injury via AMP-activated protein kinase, Akt, and nitric oxide Cardiovasc Res, April 1, 2008; 78(1): 116 - 122. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. I. Yilmaz, M. Saglam, J. J. Carrero, A. R. Qureshi, K. Caglar, T. Eyileten, A. Sonmez, E. Cakir, M. Yenicesu, B. Lindholm, et al. Serum visfatin concentration and endothelial dysfunction in chronic kidney disease Nephrol. Dial. Transplant., March 1, 2008; 23(3): 959 - 965. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. V. Wang and P. E. Scherer Adiponectin, Cardiovascular Function, and Hypertension Hypertension, January 1, 2008; 51(1): 8 - 14. [Full Text] [PDF]
|
|
|
|
 |
|
 R. Li, W.-Q. Wang, H. Zhang, X. Yang, Q. Fan, T. A. Christopher, B. L. Lopez, L. Tao, B. J. Goldstein, F. Gao, et al. Adiponectin improves endothelial function in hyperlipidemic rats by reducing oxidative/nitrative stress and differential regulation of eNOS/iNOS activity Am J Physiol Endocrinol Metab, December 1, 2007; 293(6): E1703 - E1708. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Shimabukuro, I. Chinen, N. Higa, N. Takasu, K. Yamakawa, and S. Ueda Effects of dietary composition on postprandial endothelial function and adiponectin concentrations in healthy humans: a crossover controlled study Am. J. Clinical Nutrition, October 1, 2007; 86(4): 923 - 928. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Fesus, G. Dubrovska, K. Gorzelniak, R. Kluge, Y. Huang, F. C. Luft, and M. Gollasch Adiponectin is a novel humoral vasodilator Cardiovasc Res, September 1, 2007; 75(4): 719 - 727. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Katagiri, T. Yamada, and Y. Oka Adiposity and Cardiovascular Disorders: Disturbance of the Regulatory System Consisting of Humoral and Neuronal Signals Circ. Res., July 6, 2007; 101(1): 27 - 39. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Shibata, K. Sato, M. Kumada, Y. Izumiya, M. Sonoda, S. Kihara, N. Ouchi, and K. Walsh Adiponectin accumulates in myocardial tissue that has been damaged by ischemia-reperfusion injury via leakage from the vascular compartment Cardiovasc Res, June 1, 2007; 74(3): 471 - 479. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W.-S. Chow, B. M.Y. Cheung, A. W.K. Tso, A. Xu, N. M.S. Wat, C. H.Y. Fong, L. H.Y. Ong, S. Tam, K. C.B. Tan, E. D. Janus, et al. Hypoadiponectinemia as a Predictor for the Development of Hypertension: A 5-Year Prospective Study Hypertension, June 1, 2007; 49(6): 1455 - 1461. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Y. Bang, J. L. Saver, B. Ovbiagele, Y. J. Choi, S. R. Yoon, and K. H. Lee Adiponectin levels in patients with intracranial atherosclerosis Neurology, May 29, 2007; 68(22): 1931 - 1937. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Wiecek, M. Adamczak, and J. Chudek Adiponectin--an adipokine with unique metabolic properties Nephrol. Dial. Transplant., April 1, 2007; 22(4): 981 - 988. [Full Text] [PDF]
|
|
|
|
 |
|
 P. E. Szmitko, H. Teoh, D. J. Stewart, and S. Verma Adiponectin and cardiovascular disease: state of the art? Am J Physiol Heart Circ Physiol, April 1, 2007; 292(4): H1655 - H1663. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Hopkins, N. Ouchi, R. Shibata, and K. Walsh Adiponectin actions in the cardiovascular system Cardiovasc Res, April 1, 2007; 74(1): 11 - 18. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. H. Han, M. J. Quon, J.-a Kim, and K. K. Koh Adiponectin and Cardiovascular Disease: Response to Therapeutic Interventions J. Am. Coll. Cardiol., February 6, 2007; 49(5): 531 - 538. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. E. Trujillo and P. E. Scherer Adipose Tissue-Derived Factors: Impact on Health and Disease Endocr. Rev., December 1, 2006; 27(7): 762 - 778. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. A. Uchida, Y. Nakamura, M. Kaihara, H. Norii, Y. Hanayama, H. Sugiyama, Y. Maeshima, Y. Yamasaki, and H. Makino Steroid pulse therapy impaired endothelial function while increasing plasma high molecule adiponectin concentration in patients with IgA nephropathy Nephrol. Dial. Transplant., December 1, 2006; 21(12): 3475 - 3480. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Dimitriadis, P. Mitrou, V. Lambadiari, E. Boutati, E. Maratou, D. B. Panagiotakos, E. Koukkou, M. Tzanela, N. Thalassinos, and S. A. Raptis Insulin Action in Adipose Tissue and Muscle in Hypothyroidism J. Clin. Endocrinol. Metab., December 1, 2006; 91(12): 4930 - 4937. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Pilz, H. Mangge, B. Wellnitz, U. Seelhorst, B. R. Winkelmann, B. Tiran, B. O. Boehm, and W. Marz Adiponectin and Mortality in Patients Undergoing Coronary Angiography J. Clin. Endocrinol. Metab., November 1, 2006; 91(11): 4277 - 4286. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Wang, K. S. L. Lam, L. Chan, K. W. Chan, J. B. B. Lam, M. C. Lam, R. C. L. Hoo, W. W. N. Mak, G. J. S. Cooper, and A. Xu Post-translational Modifications of the Four Conserved Lysine Residues within the Collagenous Domain of Adiponectin Are Required for the Formation of Its High Molecular Weight Oligomeric Complex J. Biol. Chem., June 16, 2006; 281(24): 16391 - 16400. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Qi, A. Doria, J. E. Manson, J. B. Meigs, D. Hunter, C. S. Mantzoros, and F. B. Hu Adiponectin genetic variability, plasma adiponectin, and cardiovascular risk in patients with type 2 diabetes. Diabetes, May 1, 2006; 55(5): 1512 - 1516. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. G. Woo, L. M. Dolan, R. Deka, R. D. Kaushal, Y. Shen, P. Pal, S. R. Daniels, and L. J. Martin Interactions Between Noncontiguous Haplotypes in the Adiponectin Gene ACDC Are Associated With Plasma Adiponectin Diabetes, February 1, 2006; 55(2): 523 - 529. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. G. Schalkwijk, N. Chaturvedi, M. T. Schram, J. H. Fuller, C. D. A. Stehouwer, and the EURODIAB Prospective Complications Study Group Adiponectin Is Inversely Associated with Renal Function in Type 1 Diabetic Patients J. Clin. Endocrinol. Metab., January 1, 2006; 91(1): 129 - 135. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Galisteo, M. Sanchez, R. Vera, M. Gonzalez, A. Anguera, J. Duarte, and A. Zarzuelo A Diet Supplemented with Husks of Plantago ovata Reduces the Development of Endothelial Dysfunction, Hypertension, and Obesity by Affecting Adiponectin and TNF-{alpha} in Obese Zucker Rats J. Nutr., October 1, 2005; 135(10): 2399 - 2404. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. D'Anna, G. Baviera, F. Corrado, D. Giordano, A. Di Benedetto, and V. M. Jasonni Plasma Adiponectin Concentration in Early Pregnancy and Subsequent Risk of Hypertensive Disorders Obstet. Gynecol., August 1, 2005; 106(2): 340 - 344. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Singhal, N. Jamieson, M. Fewtrell, J. Deanfield, A. Lucas, and N. Sattar Adiponectin Predicts Insulin Resistance But Not Endothelial Function in Young, Healthy Adolescents J. Clin. Endocrinol. Metab., August 1, 2005; 90(8): 4615 - 4621. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Pilz, R. Horejsi, R. Moller, G. Almer, H. Scharnagl, T. Stojakovic, R. Dimitrova, G. Weihrauch, M. Borkenstein, W. Maerz, et al. Early Atherosclerosis in Obese Juveniles Is Associated with Low Serum Levels of Adiponectin J. Clin. Endocrinol. Metab., August 1, 2005; 90(8): 4792 - 4796. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Iwashima, T. Katsuya, K. Ishikawa, I. Kida, M. Ohishi, T. Horio, N. Ouchi, K. Ohashi, S. Kihara, T. Funahashi, et al. Association of Hypoadiponectinemia With Smoking Habit in Men Hypertension, June 1, 2005; 45(6): 1094 - 1100. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kadowaki and T. Yamauchi Adiponectin and Adiponectin Receptors Endocr. Rev., May 1, 2005; 26(3): 439 - 451. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Qi, T. Li, E. Rimm, C. Zhang, N. Rifai, D. Hunter, A. Doria, and F. B. Hu The +276 Polymorphism of the APM1 Gene, Plasma Adiponectin Concentration, and Cardiovascular Risk in Diabetic Men Diabetes, May 1, 2005; 54(5): 1607 - 1610. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. K. Olijhoek, J. Koerselman, P. P.Th. de Jaegere, M. C. Verhaar, D. E. Grobbee, Y. van der Graaf, F. L.J. Visseren, and for the SMART Study Group Presence of the Metabolic Syndrome Does Not Impair Coronary Collateral Vessel Formation in Patients With Documented Coronary Artery Disease Diabetes Care, March 1, 2005; 28(3): 683 - 689. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. I. Yilmaz, A. Sonmez, S. Kilic, T. Celik, N. Bingol, M. Pinar, T. Mumcuoglu, and M. Ozata The association of plasma adiponectin levels with hypertensive retinopathy Eur. J. Endocrinol., February 1, 2005; 152(2): 233 - 240. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.-T. Berthier, A. Houde, M. Cote, A.-M. Paradis, P. Mauriege, J. Bergeron, D. Gaudet, J.-P. Despres, and M.-C. Vohl Impact of adiponectin gene polymorphisms on plasma lipoprotein and adiponectin concentrations of viscerally obese men J. Lipid Res., February 1, 2005; 46(2): 237 - 244. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Miller, A. Rosenbloom, and J. Silverstein Childhood Obesity J. Clin. Endocrinol. Metab., September 1, 2004; 89(9): 4211 - 4218. [Full Text] [PDF]
|
|
|
|
|
|
J. Malyszko, J. S. Malyszko, S. Brzosko, S. Wolczynski, and M. Mysliwiec Adiponectin Is Related to CD146, a Novel Marker of Endothelial Cell Activation/Injury in Chronic Renal Failure and Peritoneally Dialyzed Patients J. Clin. Endocrinol. Metab., September 1, 2004; 89(9): 4620 - 4627. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Hug, J. Wang, N. S. Ahmad, J. S. Bogan, T.-S. Tsao, and H. F. Lodish T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin PNAS, July 13, 2004; 101(28): 10308 - 10313. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Shibata, N. Ouchi, S. Kihara, K. Sato, T. Funahashi, and K. Walsh Adiponectin Stimulates Angiogenesis in Response to Tissue Ischemia through Stimulation of AMP-activated Protein Kinase Signaling J. Biol. Chem., July 2, 2004; 279(27): 28670 - 28674. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. J. Goldstein and R. Scalia Adiponectin: A Novel Adipokine Linking Adipocytes and Vascular Function J. Clin. Endocrinol. Metab., June 1, 2004; 89(6): 2563 - 2568. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Iwashima, T. Katsuya, K. Ishikawa, N. Ouchi, M. Ohishi, K. Sugimoto, Y. Fu, M. Motone, K. Yamamoto, A. Matsuo, et al. Hypoadiponectinemia Is an Independent Risk Factor for Hypertension Hypertension, June 1, 2004; 43(6): 1318 - 1323. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. T. de Jongh, E. H. Serne, R. G. IJzerman, G. de Vries, and C. D.A. Stehouwer Impaired Microvascular Function in Obesity: Implications for Obesity-Associated Microangiopathy, Hypertension, and Insulin Resistance Circulation, June 1, 2004; 109(21): 2529 - 2535. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Ohashi, N. Ouchi, S. Kihara, T. Funahashi, T. Nakamura, S. Sumitsuji, T. Kawamoto, S. Matsumoto, H. Nagaretani, M. Kumada, et al. Adiponectin I164T mutation is associated with the metabolic syndrome and coronary artery disease J. Am. Coll. Cardiol., April 7, 2004; 43(7): 1195 - 1200. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-M. Fernandez-Real, A. Castro, G. Vazquez, R. Casamitjana, A. Lopez-Bermejo, G. Penarroja, and W. Ricart Adiponectin Is Associated With Vascular Function Independent of Insulin Sensitivity Diabetes Care, March 1, 2004; 27(3): 739 - 745. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. C. B. Tan, A. Xu, W. S. Chow, M. C. W. Lam, V. H. G. Ai, S. C. F. Tam, and K. S. L. Lam Hypoadiponectinemia Is Associated with Impaired Endothelium-Dependent Vasodilation J. Clin. Endocrinol. Metab., February 1, 2004; 89(2): 765 - 769. [Abstract] [Full Text] [PDF]
|
|