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(Hypertension. 2003;42:459.)
© 2003 American Heart Association, Inc.

Scientific Contributions

Individual Blood Pressure Responses to Changes in Salt Intake

Results From the DASH-Sodium Trial

Eva Obarzanek; Michael A. Proschan; William M. Vollmer; Thomas J. Moore; Frank M. Sacks; Lawrence J. Appel; Laura P. Svetkey; Marlene M. Most-Windhauser; Jeffrey A. Cutler

From the Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute (E.O., M.A.P., J.A.C.), Bethesda, Md; Kaiser Permanente Center for Health Research (W.M.V.), Portland, Ore; Office of Clinical Research, Boston University Medical Center (T.J.M.), Boston, Mass; Nutrition Department, Harvard School of Public Health (F.M.S.), Boston, Mass; Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University School of Medicine (L.J.A.), Baltimore, Md; Duke Hypertension Center and Sarah W. Stedman Center for Nutritional Studies, Duke University Medical Center (L.P.S.), Durham, NC; and Pennington Biomedical Research Center (M.M.M.-W.), Baton Rouge, La.

Correspondence to Dr Eva Obarzanek, Research Nutritionist, Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 8136, MSC 7936, Bethesda, MD 20892-7936. E-mail obarzane{at}nhlbi.nih.gov

Although group characteristics are known to influence average blood pressure response to changes in salt intake, predictability of individual responses is less clear. We examined variability and consistency of individual systolic blood pressure responses to changes in salt intake in 188 participants who ate the same diet at higher, medium, and lower (140, 104, 62 mmol/d) sodium levels for 30 days each, in random order, after 2 weeks of run-in at the higher sodium level. Regarding variability in systolic blood pressure changes over time, changes from run-in to higher sodium (no sodium level change) ranged from -24 to +25 mm Hg; 8.0% of participants decreased 10 mm Hg. Regarding variability in systolic blood pressure response to change in sodium intake, with higher versus lower sodium levels (78-mmol sodium difference), the range of systolic blood pressure change was -32 to +17 mm Hg; 33.5% decreased 10 mm Hg. Regarding consistency of response, systolic blood pressure change with run-in versus lower sodium was modestly correlated with systolic blood pressure change with higher versus medium sodium; systolic blood pressure change with higher versus lower sodium was similarly correlated with run-in versus medium sodium (combined Spearman r=0.27, P=0.002). These results show low-order consistency of response and confirm that identifying individuals as sodium responders is difficult. They support current recommendations for lower salt intake directed at the general public rather than "susceptible" individuals as one of several strategies to prevent and control adverse blood pressures widely prevalent in the adult population.

Key Words: blood pressure • systole • sodium, dietary • blood pressure determination

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