Hypertension. 2004;43:182-185
Published online before print January 19, 2004, doi: 10.1161/01.HYP.0000113081.42868.f4
Published online before print January 19, 2004, doi: 10.1161/01.HYP.0000113081.42868.f4
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
(Hypertension. 2004;43:182.)
© 2004 American Heart Association, Inc.
Scientific Contributions |
Short Telomeres Are Associated With Increased Carotid Atherosclerosis in Hypertensive Subjects
From Centre d’Investigations Préventives et Cliniques (A.B., C.A., M.T., K.E.B, F.T.), Paris, France; Department of Geriatrics (A.B., C.L.), Medical School of Nancy, France; INSERM U258 (M.Z.), Villejuif, France; Hypertension Research Center (J.P.G., L.X., A.A.), University of Medicine and Dentistry of New Jersey, Newark.
Correspondence to Dr Athanase Benetos, Centre d’Investigations Préventives et Cliniques (IPC), 6/14 rue la Pérouse, 75116 Paris, France. E-mail benetos{at}ipc.asso.fr
Recent studies have shown that individuals with shorter telomeres present a higher prevalence of arterial lesions and higher risk of cardiovascular disease mortality. As a group, patients with high blood pressure are at an increased risk for cardiovascular diseases. However, some hypertensive patients are more prone than others to atherosclerotic lesions. The main objective of this study was to examine the relationship between telomere length, as expressed in white blood cells, and carotid artery atherosclerotic plaques in hypertensive males. Data from 163 treated hypertensive men who were volunteers for a free medical examination were analyzed. Extracranial carotid plaques were assessed with B-mode ultrasound. Telomere length was measured from DNA samples extracted from white blood cells. The results of this study show that telomere length was shorter in hypertensive men with carotid artery plaques versus hypertensive men without plaques (8.17±0.07 kb versus 8.46±0.07 kb; P<0.01). Multivariate analysis showed that in addition to age, telomere length was a significant predictor of the presence of carotid artery plaques. The findings from this study suggest that in the presence of chronic hypertension, which is a major risk factor for atherosclerotic lesions, shorter telomere length in white blood cells is associated with an increased predilection to carotid artery atherosclerosis.
Key Words: atherosclerosis • hypertension, essential • aging • carotid arteries
This article has been cited by other articles:
 |
|
 |
|
  R. S. Vasan, S. Demissie, M. Kimura, L. A. Cupples, C. White, J. P. Gardner, X. Cao, D. Levy, E. J. Benjamin, and A. Aviv Association of Leukocyte Telomere Length With Echocardiographic Left Ventricular Mass: The Framingham Heart Study Circulation, September 29, 2009; 120(13): 1195 - 1202. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. N. Re and J. L. Cook Senescence, apoptosis, and stem cell biology: the rationale for an expanded view of intracrine action Am J Physiol Heart Circ Physiol, September 1, 2009; 297(3): H893 - H901. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. T. Njajou, W.-C. Hsueh, E. H. Blackburn, A. B. Newman, S.-H. Wu, R. Li, E. M. Simonsick, T. M. Harris, S. R. Cummings, R. M. Cawthon, et al. Association Between Telomere Length, Specific Causes of Death, and Years of Healthy Life in Health, Aging, and Body Composition, a Population-Based Cohort Study J Gerontol A Biol Sci Med Sci, August 1, 2009; 64A(8): 860 - 864. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M Mukherjee, S Brouilette, S Stevens, K R Shetty, and N J Samani Association of shorter telomeres with coronary artery disease in Indian subjects Heart, April 1, 2009; 95(8): 669 - 673. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Yang, X. Huang, H. Jiang, Y. Zhang, H. Liu, C. Qin, G. M. Eisner, P. Jose, L. Rudolph, and Z. Ju Short Telomeres and Prognosis of Hypertension in a Chinese Population Hypertension, April 1, 2009; 53(4): 639 - 645. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Aviv, W. Chen, J. P. Gardner, M. Kimura, M. Brimacombe, X. Cao, S. R. Srinivasan, and G. S. Berenson Leukocyte Telomere Dynamics: Longitudinal Findings Among Young Adults in the Bogalusa Heart Study Am. J. Epidemiol., February 1, 2009; 169(3): 323 - 329. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. S.M. Wong, H. Oeseburg, R. A. de Boer, W. H. van Gilst, D. J. van Veldhuisen, and P. van der Harst Telomere biology in cardiovascular disease: the TERC-/- mouse as a model for heart failure and ageing Cardiovasc Res, February 1, 2009; 81(2): 244 - 252. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. S.M. Wong, R. A. de Boer, N. J. Samani, D. J. van Veldhuisen, and P. van der Harst Telomere biology in heart failure Eur J Heart Fail, November 1, 2008; 10(11): 1049 - 1056. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Aviv The Epidemiology of Human Telomeres: Faults and Promises J. Gerontol. A Biol. Sci. Med. Sci., September 1, 2008; 63(9): 979 - 983. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. F. Terry, V. G. Nolan, S. L. Andersen, T. T. Perls, and R. Cawthon Association of Longer Telomeres With Better Health in Centenarians J. Gerontol. A Biol. Sci. Med. Sci., August 1, 2008; 63(8): 809 - 812. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. J. O'Donnell, S. Demissie, M. Kimura, D. Levy, J. P. Gardner, C. White, R. B. D'Agostino, P. A. Wolf, J. Polak, L. A. Cupples, et al. Leukocyte Telomere Length and Carotid Artery Intimal Medial Thickness: The Framingham Heart Study Arterioscler Thromb Vasc Biol, June 1, 2008; 28(6): 1165 - 1171. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. J Samani and P. van der Harst Biological ageing and cardiovascular disease Heart, May 1, 2008; 94(5): 537 - 539. [Full Text] [PDF]
|
|
|
|
|
|
M. Kimura, J. v. B. Hjelmborg, J. P. Gardner, L. Bathum, M. Brimacombe, X. Lu, L. Christiansen, J. W. Vaupel, A. Aviv, and K. Christensen Telomere Length and Mortality: A Study of Leukocytes in Elderly Danish Twins Am. J. Epidemiol., April 1, 2008; 167(7): 799 - 806. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S. Vasan, S. Demissie, M. Kimura, L. A. Cupples, N. Rifai, C. White, T. J. Wang, J. P. Gardner, X. Cao, E. J. Benjamin, et al. Association of Leukocyte Telomere Length With Circulating Biomarkers of the Renin-Angiotensin-Aldosterone System: The Framingham Heart Study Circulation, March 4, 2008; 117(9): 1138 - 1144. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. K. Garcia, W. E. Wright, and J. W. Shay Human diseases of telomerase dysfunction: insights into tissue aging Nucleic Acids Res., December 3, 2007; 35(22): 7406 - 7416. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Tentolouris, R. Nzietchueng, V. Cattan, G. Poitevin, P. Lacolley, A. Papazafiropoulou, D. Perrea, N. Katsilambros, and A. Benetos White Blood Cells Telomere Length Is Shorter in Males With Type 2 Diabetes and Microalbuminuria Diabetes Care, November 1, 2007; 30(11): 2909 - 2915. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Bataille, B. S. Kato, M. Falchi, J. Gardner, M. Kimura, M. Lens, U. Perks, A. M. Valdes, D. C. Bennett, A. Aviv, et al. Nevus Size and Number Are Associated with Telomere Length and Represent Potential Markers of a Decreased Senescence In vivo Cancer Epidemiol. Biomarkers Prev., July 1, 2007; 16(7): 1499 - 1502. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Shen, M. B. Terry, I. Gurvich, Y. Liao, R. T. Senie, and R. M. Santella Short Telomere Length and Breast Cancer Risk: A Study in Sister Sets Cancer Res., June 1, 2007; 67(11): 5538 - 5544. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Gardner, M. Kimura, W. Chai, J. F. Durrani, L. Tchakmakjian, X. Cao, X. Lu, G. Li, A. P. Peppas, J. Skurnick, et al. Telomere Dynamics in Macaques and Humans J. Gerontol. A Biol. Sci. Med. Sci., April 1, 2007; 62(4): 367 - 374. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Collerton, C. Martin-Ruiz, A. Kenny, K. Barrass, T. von Zglinicki, T. Kirkwood, B. Keavney, and Newcastle 85+ Core Study Team Telomere length is associated with left ventricular function in the oldest old: the Newcastle 85+ study Eur. Heart J., January 10, 2007; (2007) ehl437v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Minamino and I. Komuro Vascular Cell Senescence: Contribution to Atherosclerosis Circ. Res., January 5, 2007; 100(1): 15 - 26. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Fitzpatrick, R. A. Kronmal, J. P. Gardner, B. M. Psaty, N. S. Jenny, R. P. Tracy, J. Walston, M. Kimura, and A. Aviv Leukocyte Telomere Length and Cardiovascular Disease in the Cardiovascular Health Study Am. J. Epidemiol., January 1, 2007; 165(1): 14 - 21. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Aviv, A. M Valdes, and T. D Spector Human telomere biology: pitfalls of moving from the laboratory to epidemiology Int. J. Epidemiol., December 1, 2006; 35(6): 1424 - 1429. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Fuster and V. Andres Telomere Biology and Cardiovascular Disease Circ. Res., November 24, 2006; 99(11): 1167 - 1180. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G Zhai, A Aviv, D J Hunter, D J Hart, J P Gardner, M Kimura, X Lu, A M Valdes, and T D Spector Reduction of leucocyte telomere length in radiographic hand osteoarthritis: a population-based study Ann Rheum Dis, November 1, 2006; 65(11): 1444 - 1448. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Gorenne, M. Kavurma, S. Scott, and M. Bennett Vascular smooth muscle cell senescence in atherosclerosis Cardiovasc Res, October 1, 2006; 72(1): 9 - 17. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Aviv Telomeres and human somatic fitness. J. Gerontol. A Biol. Sci. Med. Sci., August 1, 2006; 61(8): 871 - 873. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Benetos, J. P. Gardner, M. Kimura, C. Labat, R. Nzietchueng, B. Dousset, F. Zannad, P. Lacolley, and A. Aviv Aldosterone and Telomere Length in White Blood Cells J. Gerontol. A Biol. Sci. Med. Sci., December 1, 2005; 60(12): 1593 - 1596. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. S. Najjar, A. Scuteri, and E. G. Lakatta Arterial Aging: Is It an Immutable Cardiovascular Risk Factor? Hypertension, September 1, 2005; 46(3): 454 - 462. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Gardner, S. Li, S. R. Srinivasan, W. Chen, M. Kimura, X. Lu, G. S. Berenson, and A. Aviv Rise in Insulin Resistance Is Associated With Escalated Telomere Attrition Circulation, May 3, 2005; 111(17): 2171 - 2177. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D. Edo and V. Andres Aging, telomeres, and atherosclerosis Cardiovasc Res, May 1, 2005; 66(2): 213 - 221. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. S. Franklin Arterial Stiffness and Hypertension: A Two-Way Street? Hypertension, March 1, 2005; 45(3): 349 - 351. [Full Text] [PDF]
|
|
|
|
 |
|
 A. Aviv Telomeres and Human Aging: Facts and Fibs Sci. Aging Knowl. Environ., December 22, 2004; 2004(51): pe43 - pe43. [Abstract] [Full Text]
|
|