This Article Full Text Full Text (PDF) Data Supplement All Versions of this Article: 43/4/825    most recent 01.HYP.0000120122.39231.88v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Pouta, A. Articles by Järvelin, M.-R. Search for Related Content PubMed PubMed Citation Articles by Pouta, A. Articles by Järvelin, M.-R. Related Collections Lipids Other hypertension Clinical Studies Epidemiology

(Hypertension. 2004;43:825.)
© 2004 American Heart Association, Inc.

Scientific Contributions

Manifestations of Metabolic Syndrome After Hypertensive Pregnancy

Anneli Pouta; Anna-Liisa Hartikainen; Ulla Sovio; Mika Gissler; Jaana Laitinen; Mark I. McCarthy; Aimo Ruokonen; Paul Elliott; Marjo-Riitta Järvelin

From the Department of Public Health Science and General Practice (A.P., M.-R.J.), University of Oulu, Finland; Department of Obstetrics and Gynaecology (A.-L. H.), University Hospital of Oulu, Finland; Department of Epidemiology and Public Health (U.S., P.E.,M.-R. J.), Imperial College London, UK; National Research and Development Centre for Welfare and Health (M.G.), Helsinki, Finland; Oulu Regional Institute of Occupational Health (J.L.), Finland; Oxford Centre for Diabetes, Endocrinology and Metabolism (M.I.M.), University of Oxford, Oxford, UK; Department of Clinical Chemistry (A.R.), University Hospital of Oulu, Finland.

Correspondence to Dr Anneli Pouta, Obstetrician, Post doc researcher, Academy of Finland, Department of Public Health Science and General Practice, University of Oulu, Aapistie 1, PO Box 5000, FIN-90014 University of Oulu, Finland. E-mail Anneli.Pouta{at}Oulu.Fi

Small follow-up studies of hospital-based series indicate women with preeclampsia have an increased risk of insulin resistance postpartum. However, long-term data are lacking among women with gestational hypertension without proteinuria. Using a general population-based sample of 5889 women from Northern Finland followed longitudinally since birth in 1966, we examined these associations and the influence of the subject’s own birth weight and gestational age on this relationship. At age 31, blood pressure was measured and blood samples collected from 2678 women, of which 1463 women had had at least 1 singleton pregnancy. Of these, 45 had been hospitalized because of gestational hypertension and 49 because of preeclampsia. Women who had had either gestational hypertension or preeclampsia during their first pregnancy (average age 25 years) had increased blood pressure at 31 years compared with women with previous normotensive pregnancy, even after adjustment for body mass index (P<0.001 in gestational hypertension, P=0.023 in preeclampsia group). When compared with the whole female population, women with previous gestational hypertension at same age still had higher blood pressure, while this difference was weaker for women with previous preeclampsia. Women with gestational hypertension and preeclampsia also had higher waist circumference, waist/hip ratio, and body mass index, as well as increased serum insulin levels and lower glucose/insulin ratio than women with previous normotensive pregnancy. The associations remained after adjustment for participant’s own birth weight or gestational age. Women born before gestational week 37 had a 2-fold risk for gestational hypertension in their first pregnancy (RR: 2.53; 95% CI: 1.0, 6.2).

Key Words: cohort studies • hypertension • low birth weight • insulin resistance • longitudinal studies • preeclampsia • pregnancy

This article has been cited by other articles:

				J. A. Lykke, J. Langhoff-Roos, B. M. Sibai, E. F. Funai, E. W. Triche, and M. J. Paidas Hypertensive Pregnancy Disorders and Subsequent Cardiovascular Morbidity and Type 2 Diabetes Mellitus in the Mother Hypertension, June 1, 2009; 53(6): 944 - 951. [Abstract] [Full Text] [PDF]

				E. Kajantie, J. G. Eriksson, C. Osmond, K. Thornburg, and D. J.P. Barker Pre-Eclampsia Is Associated With Increased Risk of Stroke in the Adult Offspring: The Helsinki Birth Cohort Study Stroke, April 1, 2009; 40(4): 1176 - 1180. [Abstract] [Full Text] [PDF]

				B. E. Vikse, L. M. Irgens, T. Leivestad, R. Skjaerven, and B. M. Iversen Preeclampsia and the Risk of End-Stage Renal Disease N. Engl. J. Med., August 21, 2008; 359(8): 800 - 809. [Abstract] [Full Text] [PDF]

				B. D. LaMarca, J. Gilbert, and J. P. Granger Recent Progress Toward the Understanding of the Pathophysiology of Hypertension During Preeclampsia Hypertension, April 1, 2008; 51(4): 982 - 988. [Full Text] [PDF]

				A. K. Klemmensen, S. F. Olsen, M. L. Osterdal, and A. Tabor Validity of Preeclampsia-related Diagnoses Recorded in a National Hospital Registry and in a Postpartum Interview of the Women Am. J. Epidemiol., July 15, 2007; 166(2): 117 - 124. [Abstract] [Full Text] [PDF]

				H Koski-Rahikkala, A Pouta, K Pietilainen, and A-L Hartikainen Does parity affect mortality among parous women? J Epidemiol Community Health, November 1, 2006; 60(11): 968 - 973. [Abstract] [Full Text] [PDF]

				E. Kajantie, R. Kaaja, O. Ylikorkala, S. Andersson, and H. Laivouri Adiponectin Concentrations in Maternal Serum: Elevated in Preeclampsis But Unrelated to Insulin Sensitivity Reproductive Sciences, September 1, 2005; 12(6): 433 - 439. [Abstract] [PDF]