This Article Full Text Full Text (PDF) All Versions of this Article: 45/4/602    most recent 01.HYP.0000158261.86674.8ev1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Kotsis, V. Articles by Zakopoulos, N. Search for Related Content PubMed PubMed Citation Articles by Kotsis, V. Articles by Zakopoulos, N. Related Collections Clinical Studies Obesity

(Hypertension. 2005;45:602.)
© 2005 American Heart Association, Inc.

Original Articles

Impact of Obesity on 24-Hour Ambulatory Blood Pressure and Hypertension

Vasilios Kotsis; Stella Stabouli; Marshall Bouldin; Annette Low; Savvas Toumanidis; Nikos Zakopoulos

From the Department of Clinical Therapeutics (V.K., S.S., S.T., N.Z.), Alexandra Hospital, National and Kapodestrial University, Athens, Greece; the Department of Physiology and Biophysics and Center of Excellence in Cardiovascular-Renal Research (V.K.) and the Department of Medicine (V.K., S.S., M.B., A.L.), Metabolic Disorders Clinic, the University of Mississippi Medical Center, Jackson, Miss.

Correspondence to Kotsis Vasilios, MD, PhD, Department of Physiology and Biophysics and Center of Excellence in Cardiovascular-Renal Research, The University of Mississippi Medical Center, 2500 North State St, Jackson, MS 39216-4505 Jackson. E-mail vkotsis{at}physiology.umsmed.edu

The purpose of the present study was to determine the relationship between body mass index (BMI) and parameters derived from 24-hour ambulatory blood pressure monitoring including mean 24-hour daytime and nighttime systolic and diastolic blood pressures, 24-hour daytime and nighttime pulse pressure, mean 24-hour daytime and nighttime heart rate, dipping and nondipping status. 3216 outpatient subjects who visited our hypertension center and were never treated with antihypertensive medication underwent 24-hour blood pressure monitoring. BMI was significantly correlated with clinic systolic and diastolic blood pressures. Significant correlations were also found between BMI and mean 24-hour daytime and nighttime systolic blood pressure, 24-hour daytime and nighttime pulse pressure, and mean 24-hour daytime and nighttime heart rate. In multivariate regression analysis, clinic systolic, diastolic blood pressure, mean 24-hour systolic blood pressure, 24-hour pulse pressure, and high-density lipoprotein were independently correlated with BMI. The incidence of white coat hypertension was higher in overweight and obese patients than in normal weight subjects. Confirmed ambulatory blood pressure hypertension was also found to be higher in overweight and obese individuals compared with normal weight subjects. Our data also highlight the higher incidence of nondipping status in obesity. These findings suggest that obese patients had increased ambulatory blood pressure parameters and altered circadian blood pressure rhythm with increased prevalence of nondipping status.

Key Words: blood pressure monitoring, ambulatory • body mass index • hypertension • obesity

This article has been cited by other articles:

				H Wang, J Necheles, M Carnethon, B Wang, Z Li, L Wang, X Liu, J Yang, G Tang, H Xing, et al. Adiposity measures and blood pressure in Chinese children and adolescents Arch. Dis. Child., September 1, 2008; 93(9): 738 - 744. [Abstract] [Full Text] [PDF]

				E. D. Abel, S. E. Litwin, and G. Sweeney Cardiac Remodeling in Obesity Physiol Rev, April 1, 2008; 88(2): 389 - 419. [Abstract] [Full Text] [PDF]

				E. Brondolo, D. J. Libby, E.-g. Denton, S. Thompson, D. L. Beatty, J. Schwartz, M. Sweeney, J. N. Tobin, A. Cassells, T. G. Pickering, et al. Racism and Ambulatory Blood Pressure in a Community Sample Psychosom Med, January 1, 2008; 70(1): 49 - 56. [Abstract] [Full Text] [PDF]

				M. Luque-Ramirez, F. Alvarez-Blasco, C. Mendieta-Azcona, J. I. Botella-Carretero, and H. F. Escobar-Morreale Obesity Is the Major Determinant of the Abnormalities in Blood Pressure Found in Young Women with the Polycystic Ovary Syndrome J. Clin. Endocrinol. Metab., June 1, 2007; 92(6): 2141 - 2148. [Abstract] [Full Text] [PDF]

				G. de Simone Morbid Obesity and Left Ventricular Geometry Hypertension, January 1, 2007; 49(1): 7 - 9. [Full Text] [PDF]

				J. R. Banegas, J. Segura, J. Sobrino, F. Rodriguez-Artalejo, A. de la Sierra, J. J. de la Cruz, M. Gorostidi, A. Sarria, L. M. Ruilope, and for the Spanish Society of Hypertension Ambulatory Effectiveness of Blood Pressure Control Outside the Medical Setting Hypertension, January 1, 2007; 49(1): 62 - 68. [Abstract] [Full Text] [PDF]

				I. Z. Ben-Dov, M. Bursztyn, V. Kotsis, S. Stabouli, M. Bouldin, A. Low, S. Toumanidis, and N. Zakopoulos Body Mass Index and Ambulatory Blood Pressure Monitoring Hypertension, July 1, 2005; 46(1): e1 - e2. [Full Text] [PDF]