This Article Full Text Full Text (PDF) All Versions of this Article: 45/6/1094    most recent 01.HYP.0000169444.05588.4cv1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Iwashima, Y. Articles by Ogihara, T. Search for Related Content PubMed PubMed Citation Articles by Iwashima, Y. Articles by Ogihara, T. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Hazardous Substances DB HYDROGEN PEROXIDE NICOTINE NICOTINE TARTRATE Medline Plus Health Information Smoking Related Collections Clinical Studies Epidemiology Lipids Lipid and lipoprotein metabolism Oxidant stress Risk Factors

(Hypertension. 2005;45:1094.)
© 2005 American Heart Association, Inc.

Original Articles

Association of Hypoadiponectinemia With Smoking Habit in Men

Yoshio Iwashima; Tomohiro Katsuya; Kazuhiko Ishikawa; Iwao Kida; Mitsuru Ohishi; Takeshi Horio; Noriyuki Ouchi; Koji Ohashi; Shinji Kihara; Tohru Funahashi; Hiromi Rakugi; Toshio Ogihara

From the Departments of Geriatric Medicine (Y.I., T.K., K.I., I.K., M.O., H.R., T.O.) and Internal Medicine and Molecular Science (N.O., K.O., S.K., T.F.), Osaka University Graduate School of Medicine, Japan; and Division of Hypertension and Nephrology (T.H.), Department of Medicine, National Cardiovascular Center, Osaka, Japan.

Correspondence to Tomohiro Katsuya, MD, PhD, Department of Geriatric Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita 565-0871, Japan. E-mail katsuya{at}geriat.med.osaka-u.ac.jp

Adiponectin is emerging as an important molecule in obesity, the metabolic syndrome, and cardiovascular disease. On the other hand, smoking habit is well known to be related to cardiovascular disease and hypertension. To examine the association between adiponectin concentration and smoking habit, we performed an epidemiological survey and an acute exposure test in humans and an experiment in adipocytes to elucidate the mechanism underlying the association between adiponectin and smoking. In the epidemiological study, we enrolled a total of 331 male subjects to examine chronic smoking exposure. Plasma adiponectin was significantly lower (P=0.01) in current smokers (5.3±0.3 µg/mL) than in never-smokers (6.5±0.4 µg/mL). A significant association between smoking and low adiponectin level was also confirmed in multiple regression analysis including age, body mass index, hypertension, diabetes, hyperlipidemia, and creatinine clearance (never-smokers 6.5±0.4 µg/mL; past smokers 5.6±0.3 µg/mL; current smokers 5.2±0.4 µg/mL; F=4.52; P=0.01). To examine the acute effect of smoking on adiponectin concentration for 12 hours, we measured plasma adiponectin level in 5 male never-smokers before smoking and 3, 6, and 12 hours after smoking, with the result that adiponectin showed a significant decrease after smoking (12 hours; –14.5±0.6%; P<0.01). In cultured mouse 3T3-L1 adipocytes, H₂O₂ and nicotine reduced the mRNA expression and secretion of adiponectin in a dose-dependent manner. Smoking habit is associated with adiponectin concentration in men, and its suppressive effect is mediated in part through direct inhibition of smoking on adiponectin expression in adipocytes.

Key Words: smoking • oxidative stress • risk factors • lipids • lipoprotein • metabolism

This article has been cited by other articles:

				M. Matsumoto, S. Ishikawa, and E. Kajii Association of Adiponectin With Cerebrovascular Disease: A Nested Case-Control Study Stroke, February 1, 2008; 39(2): 323 - 328. [Abstract] [Full Text] [PDF]

				R. Shibata, K. Sato, M. Kumada, Y. Izumiya, M. Sonoda, S. Kihara, N. Ouchi, and K. Walsh Adiponectin accumulates in myocardial tissue that has been damaged by ischemia-reperfusion injury via leakage from the vascular compartment Cardiovasc Res, June 1, 2007; 74(3): 471 - 479. [Abstract] [Full Text] [PDF]

				A. Wiecek, M. Adamczak, and J. Chudek Adiponectin--an adipokine with unique metabolic properties Nephrol. Dial. Transplant., April 1, 2007; 22(4): 981 - 988. [Full Text] [PDF]

				S. H. Han, M. J. Quon, J.-a Kim, and K. K. Koh Adiponectin and Cardiovascular Disease: Response to Therapeutic Interventions J. Am. Coll. Cardiol., February 6, 2007; 49(5): 531 - 538. [Abstract] [Full Text] [PDF]

				F. Abbasi, H. M. F. Farin, C. Lamendola, T. McLaughlin, E. A. Schwartz, G. M. Reaven, and P. D. Reaven The Relationship between Plasma Adiponectin Concentration and Insulin Resistance Is Altered in Smokers J. Clin. Endocrinol. Metab., December 1, 2006; 91(12): 5002 - 5007. [Abstract] [Full Text] [PDF]