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(Hypertension. 2005;46:168.)
© 2005 American Heart Association, Inc.

Original Articles

Baroreceptor Denervation Prevents Sympathoinhibition During Angiotensin II–Induced Hypertension

Carolyn J. Barrett; Sarah-Jane Guild; Rohit Ramchandra; Simon C. Malpas

From the Circulatory Control Laboratory, Department of Physiology, University of Auckland, New Zealand.

Correspondence to Dr Carolyn Barrett, Department of Physiology, University of Auckland Medical School, Private Bag 92019, Auckland, New Zealand. E-mail c.barrett{at}auckland.ac.nz

Arterial baroreflexes are well established to provide the basis for short-term control of arterial pressure; however, their role in long-term pressure control is more controversial. We proposed that if the sustained decrease in renal sympathetic nerve activity (RSNA) we observed previously in response to angiotensin II–induced hypertension is baroreflex mediated, then the decrease in RSNA in response to angiotensin II would not occur in sinoaortic-denervated (SAD) animals. Arterial pressure and RSNA were recorded continuously via telemetry in sham and SAD rabbits living in their home cages before, during, and after a 7-day infusion of angiotensin II (50 ng · kg^–1 · min^–1). The arterial pressure responses in the 2 groups of rabbits were not significantly different (82±3 mm Hg sham versus 83±3 mm Hg SAD before angiotensin II infusion, and 101±6 mm Hg sham versus 100±4 mm Hg SAD day 6 of angiotensin II). In sham rabbits, there was a significant sustained decrease in RSNA (53±7% of baseline on day 2 and 65±7% on day 6 of the angiotensin II). On ceasing the angiotensin II, all variables recovered to baseline. In contrast, RSNA did not change in SAD rabbits with the angiotensin II infusion (RSNA was 98±8% of baseline on day 2 and 98±8% on day 6 of the angiotensin II infusion). These results support our hypothesis that the reduction in RSNA in response to a pressor dose of angiotensin II is dependent on an intact arterial baroreflex pathway.

Key Words: baroreceptors • denervation • rabbits • nervous system, sympathetic renal

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