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(Hypertension. 2005;46:943.)
© 2005 American Heart Association, Inc.

Part 2 Original Articles

Effects of Captopril on the Renin Angiotensin System, Oxidative Stress, and Endothelin in Normal and Hypertensive Rats

Rodney J. Bolterman; Melissa C. Manriquez; M. Clara Ortiz Ruiz; Luis A. Juncos; J. Carlos Romero

From Department of Physiology and Biomedical Engineering (R.J.B., J.C.R.), Mayo Clinic College of Medicine, Rochester, Minn; Div. of Nephrology and Hypertension (M.C.M., L.A.J.), Mayo Clinic College of Medicine, Rochester, Minn; Department of Physiology (M.C.O.R.), University of Murcia, Murcia, Spain.

Correspondence to J. Carlos Romero, MD, Professor of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905. E-mail romero.juan{at}mayo.edu

There is substantial evidence suggesting that angiotensin II plays an important role in elevating blood pressure of spontaneously hypertensive rats, despite normal plasma renin activity, and that converting enzyme inhibitors (captopril) can effectively normalize blood pressure in the spontaneously hypertensive rats. One mechanism by which angiotensin II induces hypertension is via oxidative stress and endothelin, as seen in subpressor angiotensin II–induced hypertension. In fact, it has been shown that antioxidants lower mean arterial pressure in spontaneously hypertensive rats. However, the relationship between angiotensin II, oxidative stress, and endothelin in the spontaneously hypertensive rats is still relatively undefined. This study examines the relationship between mean arterial pressure, plasma renin activity, angiotensin II, oxidative stress, and endothelin in spontaneously hypertensive rats compared with normotensive Wistar Kyoto rats, and the effects of captopril on this association. Untreated spontaneously hypertensive rats had increased plasma angiotensin II levels despite normal plasma renin activity, oxidative stress, and endothelin. Captopril treatment in spontaneously hypertensive rats lowered mean arterial pressure, angiotensin II, oxidative stress, and endothelin, and increased plasma renin activity. In contrast, captopril increased plasma renin activity (suggesting effective captopril treatment) but did not significantly alter mean arterial pressure, angiotensin II, oxidative stress, or endothelin of Wistar Kyoto rats. These results suggest that in spontaneously hypertensive rats, angiotensin II is a primary instigator of hypertension, and that captopril selectively lowers angiotensin II, oxidant stress, and endothelin, which in turn may contribute to the blood pressure-lowering efficacy of captopril in spontaneously hypertensive rats.

Key Words: angiotensin II • angiotensin-converting enzyme inhibitors • captopril • endothelin • oxidative stress • rats, spontaneously hypertensive

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