Published online before print November 14, 2005, doi: 10.1161/01.HYP.0000191706.41980.29
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
(Hypertension. 2005;46:1286.)
© 2005 American Heart Association, Inc.
Original Articles |
Genome-Wide Linkage Analysis for Loci Affecting Pulse Pressure
The Family Blood Pressure Program
From the Division of Epidemiology and Community Health (S.J.B., A.I.L., M.B.M., D.K.A.), University of Minnesota, Minneapolis; University of Michigan Hospitals (A.W.), Ann Arbor; Loyola University Medical Center (R.C.), Maywood, Ill; UAB Division of Preventive Medicine (A.O.), Birmingham, Ala; Cedars-Sinai Medical Center (Y.-D.I.C., M.P.), Los Angles, Calif; Division of Nephrology and Hypertension (S.T.T.), Mayo Clinic, Rochester, Minn; Institute of Molecular Medicine (M.F.), Houston, Tex; Division of Biostatistics (M.P.), Washington University School of Medicine, St. Louis, Mo; and Department of Epidemiology (D.K.A.), University of Alabama, Birmingham.
Correspondence to Donna K. Arnett, PhD, MSPH, Professor and Chair, Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Ryals Public Health Building 220E, 1530 Third Ave S, Birmingham, AL 35294-0022. E-mail Arnett{at}ms.soph.uab.edu
Pulse pressure, the difference between systolic and diastolic blood pressure, is an independent risk factor for cardiovascular disease. Increased pulse pressure reflects reduced compliance of arteries and is a marker of atherosclerosis. To locate genes that affect pulse pressure, a genome-wide linkage scan for quantitative trait loci influencing pulse pressure was performed using variance components methods as implemented in sequential oligogenic linkage analysis routines. The analysis sample included 10 798 participants in 3320 families who were recruited as part of the Family Blood Pressure Program and were phenotyped with an oscillometric blood pressure measurement device using a consistent protocol across centers. Pulse pressure was adjusted for the effects of sex, age, age2, age-by-sex interaction, age2-by-sex interaction, body mass index, and field center to remove sources of variation other than the genetic effects related to pulse pressure. Significant linkage was observed on chromosome 18 (logarithm of odds [LOD]=3.2) in a combined racial sample, chromosome 20 (LOD=4.4), and 17 (LOD=3.6) in Hispanics, chromosome 21 (LOD=4.3) in whites, chromosome 19 (LOD=3.1) in a combined sample of blacks and whites, and chromosome 7 (logarithm of odds [LOD]=3.1) in blacks from the GenNet Network. Our genome scan shows significant evidence for linkage for pulse pressure in multiple areas of the genome, supporting previous published linkage studies. The identification of these loci for pulse pressure and the apparent congruence with other blood pressure phenotypes provide increased support that these regions contain genes influencing blood pressure phenotypes.
Key Words: blood pressure • genetics • hypertension, genetics
This article has been cited by other articles:
 |
|
 |
|
  M. D. Johnson, L. He, D. Herman, H. Wakimoto, C. A. Wallace, V. Zidek, P. Mlejnek, A. Musilova, M. Simakova, J. Vorlicek, et al. Dissection of Chromosome 18 Blood Pressure and Salt-Sensitivity Quantitative Trait Loci in the Spontaneously Hypertensive Rat Hypertension, September 1, 2009; 54(3): 639 - 645. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. T. Turner, M. Fornage, C. R. Jack Jr, T. H. Mosley, D. S. Knopman, S. L. R. Kardia, E. Boerwinkle, and M. de Andrade Genomic Susceptibility Loci for Brain Atrophy, Ventricular Volume, and Leukoaraiosis in Hypertensive Sibships Arch Neurol, July 1, 2009; 66(7): 847 - 857. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Lacolley, P. Challande, M. Osborne-Pellegrin, and V. Regnault Genetics and pathophysiology of arterial stiffness Cardiovasc Res, March 1, 2009; 81(4): 637 - 648. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P.-a. B. Shih and D. T. O'Connor Hereditary Determinants of Human Hypertension: Strategies in the Setting of Genetic Complexity Hypertension, June 1, 2008; 51(6): 1456 - 1464. [Full Text] [PDF]
|
|
|
|
 |
|
 C. M. Vachon, T. A. Sellers, E. E. Carlson, J. M. Cunningham, C. A. Hilker, R. L. Smalley, D. J. Schaid, L. E. Kelemen, F. J. Couch, and V. S. Pankratz Strong Evidence of a Genetic Determinant for Mammographic Density, a Major Risk Factor for Breast Cancer Cancer Res., September 1, 2007; 67(17): 8412 - 8418. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Zintzaras, G. Kitsios, D. Kent, N. J. Camp, L. Atwood, P. N. Hopkins, and S. C. Hunt Genome-Wide Scans Meta-Analysis for Pulse Pressure Hypertension, September 1, 2007; 50(3): 557 - 564. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Duggal, A. P. Klein, K. E. Lee, R. Klein, B. E. K. Klein, and J. E. Bailey-Wilson Identification of Novel Genetic Loci for Intraocular Pressure: A Genomewide Scan of the Beaver Dam Eye Study Arch Ophthalmol, January 1, 2007; 125(1): 74 - 79. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Llamas, C. Lau, W. A. Cupples, M.-L. Rainville, E. Souzeau, and C. F. Deschepper Genetic Determinants of Systolic and Pulse Pressure in an Intercross Between Normotensive Inbred Rats Hypertension, November 1, 2006; 48(5): 921 - 926. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Franceschini, J. W. MacCluer, H. H.H. Goring, S. A. Cole, K. M. Rose, L. Almasy, V. Diego, S. Laston, E. T. Lee, B. V. Howard, et al. A Quantitative Trait Loci-Specific Gene-by-Sex Interaction on Systolic Blood Pressure Among American Indians: The Strong Heart Family Study Hypertension, August 1, 2006; 48(2): 266 - 270. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. T. Turner, S. L.R. Kardia, T. H. Mosley, A. D. Rule, E. Boerwinkle, and M. de Andrade Influence of Genomic Loci on Measures of Chronic Kidney Disease in Hypertensive Sibships J. Am. Soc. Nephrol., July 1, 2006; 17(7): 2048 - 2055. [Abstract] [Full Text] [PDF]
|
|