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Hypertension. 2006;47:281-287
Published online before print December 27, 2005, doi: 10.1161/01.HYP.0000198428.45132.02
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(Hypertension. 2006;47:281.)
© 2006 American Heart Association, Inc.

Original Articles

{alpha}V Integrins Are Necessary for Eutrophic Inward Remodeling of Small Arteries in Hypertension

Egidius H.J. Heerkens; Linda Shaw; Alisdair Ryding; Gillian Brooker; John J. Mullins; Clare Austin; Vasken Ohanian; Anthony M. Heagerty

From the Department of Medicine (E.H.J.H., L.S., C.A., V.O., A.M.H.), University of Manchester, Manchester Royal Infirmary, Manchester, United Kingdom; and Molecular Physiology Group A.R., G.B., J.J.M.), University of Edinburgh, Edinburgh, Midlothian, United Kingdom.

Correspondence to Anthony M. Heagerty, Department of Medicine, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, United Kingdom. E-mail tony.heagerty{at}man.ac.uk

Human essential hypertension is characterized by eutrophic remodeling of small arteries, with little evidence of hypertrophy. Likewise, vessels of young hypertensive TGR(mRen2)27 animals have undergone similar structural alterations. The role of integrins in resistance arteries of TGR(mRen2)27 during the eutrophic-remodeling process was examined as blood pressure rose. Initially, 8 {alpha} and 3 ß integrins were identified and levels of expression investigated using RT-PCR. As pressure increased and remodeling advanced, integrin expression profiles revealed that only {alpha}V was significantly raised. In conjunction, we confirmed elevated integrin {alpha}V protein levels in TGR(mRen2)27 rat arteries and localization to the media using immunofluorescence. ß1 and ß3, but not ß5 integrin subunits were coprecipitated with integrin {alpha}V and are implicated in the eutrophic remodeling process. Administration of a peptide antagonist of {alpha}Vß3 abolished remodeling but enhanced growth, indicating that hypertrophy supervened as a response to hypertension-induced increases in wall stress. We have established that the only upregulated integrin, the {alpha}V subunit of integrin {alpha}Vß3, has a crucial role in the hypertensive remodeling process of TGR(mRen2)27 rat resistance arteries. During hypertensive remodeling, functions of specific {alpha}Vß3-extracellular matrix interactions are likely to allow vascular smooth muscle cell–length autoregulation, which includes a migratory process, to maintain a narrowed lumen after a prolonged constricted state.


Key Words: integrins • hypertrophy • hypertension • extracellular matrix


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