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(Hypertension. 2006;47:840.)
© 2006 American Heart Association, Inc.

Original Articles

Effects of Continuous Positive Airway Pressure Versus Supplemental Oxygen on 24-Hour Ambulatory Blood Pressure

Daniel Norman; José S. Loredo; Richard A. Nelesen; Sonia Ancoli-Israel; Paul J. Mills; Michael G. Ziegler; Joel E. Dimsdale

From the Departments of Medicine (D.N., J.S.L., M.G.Z.), and Psychiatry (R.A.N., S.A.-I., P.J.M., J.E.D.), School of Medicine, University of California San Diego, San Diego, Calif.

Correspondence to Daniel Norman, Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California San Diego Medical Center, 200 West Arbor Dr, San Diego, CA 92103-8383. E-mail d1norman{at}ucsd.edu

Obstructive sleep apnea (OSA) is associated with recurrent episodes of nocturnal hypoxia and increased risk for development of systemic hypertension. Prior studies have been limited, however, in their ability to show reduction in blood pressure after continuous positive airway pressure (CPAP) therapy, and the effect of supplemental oxygen alone on blood pressure in OSA has not been evaluated. We performed a randomized, double-blind, placebo-controlled study comparing the effects of 2 weeks of CPAP versus sham-CPAP versus supplemental nocturnal oxygen on 24-hour ambulatory blood pressure in 46 patients with moderate-severe OSA. We found that 2 weeks of CPAP therapy resulted in a significant reduction in daytime mean arterial and diastolic blood pressure and nighttime systolic, mean, and diastolic blood pressure (all Ps <0.05). Although nocturnal supplemental oxygen therapy improved oxyhemoglobin saturation, it did not affect blood pressure. We conclude that CPAP therapy reduces both daytime and nighttime blood pressure in patients with OSA, perhaps through mechanisms other than improvement of nocturnal oxyhemoglobin saturation.

Key Words: apnea • blood pressure • oxygen

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