This Article Full Text Full Text (PDF) All Versions of this Article: 48/1/40    most recent 01.HYP.0000227029.10536.e8v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Lande, M. B. Articles by Meagher, C. C. Search for Related Content PubMed PubMed Citation Articles by Lande, M. B. Articles by Meagher, C. C. Related Collections Obesity Cardiovascular imaging agents/Techniques Hypertrophy Clinical Studies Echocardiography Related Article

(Hypertension. 2006;48:40.)
© 2006 American Heart Association, Inc.

Original Articles

Effects of Childhood Primary Hypertension on Carotid Intima Media Thickness

A Matched Controlled Study

Marc B. Lande; Nancy L. Carson; Jason Roy; Cecilia C. Meagher

From the Divisions of Pediatric Nephrology (M.B.L.) and Pediatric Cardiology (C.C.M.), Department of Pediatrics, Department of Radiology (N.L.C.), and Department of Biostatistics and Computational Biology (J.R.), University of Rochester Medical Center, NY.

Correspondence to Marc B. Lande, 601 Elmwood Ave, Box 777, Rochester, NY 14642. E-mail marc_lande{at}urmc.rochester.edu

To determine whether carotid intima media thickness is increased in children with primary hypertension, the current study compared carotid intima media thickness in hypertensive children with that of normotensive control subjects matched closely for body mass index and determined the relationship between carotid intima media thickness and hypertension severity determined by ambulatory blood pressure monitoring. Children with newly diagnosed office hypertension (n=28) had carotid intima media thickness, left ventricular mass index, and ambulatory blood pressure monitoring performed. Carotid intima media thickness was performed in normotensive control subjects (n=28) matched pairwise to hypertensive subjects for age (±1 year), gender, and body mass index (±10%). Eighty-two percent of subjects were overweight or obese (body mass index 85th percentile). The median carotid intima media thickness of hypertensive subjects was greater than that of matched controls (0.67 versus 0.63 mm; P=0.045). In the hypertensive subjects, carotid intima media thickness correlated strongly with several ambulatory blood pressure monitoring parameters, with the strongest correlation for daytime systolic blood pressure index (r=0.57; P=0.003). In the hypertensive group, the prevalence of left ventricular hypertrophy was 32%, but unlike carotid intima media thickness, left ventricular mass index did not correlate with ambulatory blood pressure monitoring. Together, the findings that hypertensive subjects had increased carotid intima media thickness compared with matched controls and that higher carotid intima media thickness correlated with more severe hypertension by ambulatory blood pressure monitoring provide strong evidence that carotid intima media thickness is increased in childhood primary hypertension, independent of the effects of obesity.

Key Words: carotid arteries • children • hypertension, obesity

Related Article:

What Is the Significance of Increased Carotid Intima Media Thickness in Hypertensive Adolescents?

Joseph T. Flynn
Hypertension 2006 48: 23-24. [Extract] [Full Text] [PDF]

This article has been cited by other articles:

				J. T. Flynn Hypertension in the young: epidemiology, sequelae and therapy Nephrol. Dial. Transplant., February 1, 2009; 24(2): 370 - 375. [Full Text] [PDF]

				M. B. Lande, T. A. Pearson, R. P. Vermilion, P. Auinger, and I. D. Fernandez Elevated Blood Pressure, Race/Ethnicity, and C-Reactive Protein Levels in Children and Adolescents Pediatrics, December 1, 2008; 122(6): 1252 - 1257. [Abstract] [Full Text] [PDF]

				E. Urbina, B. Alpert, J. Flynn, L. Hayman, G. A. Harshfield, M. Jacobson, L. Mahoney, B. McCrindle, M. Mietus-Snyder, J. Steinberger, et al. Ambulatory Blood Pressure Monitoring in Children and Adolescents: Recommendations for Standard Assessment: A Scientific Statement From the American Heart Association Atherosclerosis, Hypertension, and Obesity in Youth Committee of the Council on Cardiovascular Disease in the Young and the Council for High Blood Pressure Research Hypertension, September 1, 2008; 52(3): 433 - 451. [Full Text] [PDF]

				B. Williams The Year in Hypertension J. Am. Coll. Cardiol., May 6, 2008; 51(18): 1803 - 1817. [Full Text] [PDF]

				J. Gonzalez, J. C. Wood, F. J. Dorey, T. A. L. Wren, and V. Gilsanz Reproducibility of Carotid Intima-Media Thickness Measurements in Young Adults Radiology, May 1, 2008; 247(2): 465 - 471. [Abstract] [Full Text] [PDF]

				M. Puato, P. Palatini, M. Zanardo, F. Dorigatti, C. Tirrito, M. Rattazzi, and P. Pauletto Increase in Carotid Intima-Media Thickness in Grade I Hypertensive Subjects: White-Coat Versus Sustained Hypertension Hypertension, May 1, 2008; 51(5): 1300 - 1305. [Abstract] [Full Text] [PDF]

				S. Genovesi, F. Pieruzzi, M. Giussani, V. Tono, A. Stella, A. Porta, M. Pagani, and D. Lucini Analysis of Heart Period and Arterial Pressure Variability in Childhood Hypertension: Key Role of Baroreflex Impairment Hypertension, May 1, 2008; 51(5): 1289 - 1294. [Abstract] [Full Text] [PDF]

				T. W. Rooke Controversies in vascular screening art versus science Vascular Medicine, August 1, 2007; 12(3): 235 - 242. [Abstract] [PDF]

				J. T. Flynn What Is the Significance of Increased Carotid Intima Media Thickness in Hypertensive Adolescents? Hypertension, July 1, 2006; 48(1): 23 - 24. [Full Text] [PDF]