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(Hypertension. 2007;49:298.)
© 2007 American Heart Association, Inc.

Original Articles

Hyperuricemia and Incidence of Hypertension Among Men Without Metabolic Syndrome

From the Schools of Medicine (E.K., C.K.K.) and Public Health (C.K.K., L.K.), University of Pittsburgh, Pittsburgh, Pa; and the Department of Medicine (H.R.S.), University of Pennsylvania School of Medicine, Philadelphia.

Correspondence to Eswar Krishnan, Division of Rheumatology and Clinical Immunology, S709 Biomedical Science Tower, 3500 Terrace St, Pittsburgh, PA 15261. E-mail arthritis.MD{at}gmail.com

The aim of this project was to study the risk of developing hypertension over a 6-year follow-up in normotensive men with baseline hyperuricemia (serum uric acid >7.0 mg/dL) but without diabetes/glucose intolerance or metabolic syndrome. We analyzed the data on men without metabolic syndrome or hypertension at baseline from the Multiple Risk Factor Intervention Trial. These men (n=3073; age: 35 to 57 years) were followed for an average of 6 years by annual examinations. Follow-up blood pressure among those with baseline was consistently higher than among those with normal serum uric acid concentration. We used Cox regression models for adjustment for the effects of serum creatinine, body mass index, age, blood pressure, proteinuria, serum cholesterol and triglycerides, alcohol and tobacco use, risk factor interventions, and use of diuretics. In these models, normotensive men with baseline hyperuricemia had an 80% excess risk for incident hypertension (hazard ratio: 1.81; 95% CI: 1.59 to 2.07) compared with those who did not. Each unit increase in serum uric acid was associated with a 9% increase in the risk for incident hypertension (hazard ratio: 1.09; 95% CI: 1.02 to 1.17). We conclude that the hyperuricemia–hypertension risk relationship is present among normotensive middle-aged men without diabetes/glucose intolerance or metabolic syndrome.

Key Words: uric acid • hypertension • etiology • epidemiology • risk

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