This Article Full Text Full Text (PDF) All Versions of this Article: 49/4/832    most recent 01.HYP.0000260092.93964.edv1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Hottenga, J.-J. Articles by Boomsma, D. I. Search for Related Content PubMed PubMed Citation Articles by Hottenga, J.-J. Articles by Boomsma, D. I. Related Collections Clinical genetics Epidemiology Genetics of cardiovascular disease

(Hypertension. 2007;49:832.)
© 2007 American Heart Association, Inc.

Original Articles

Genome-Wide Scan for Blood Pressure in Australian and Dutch Subjects Suggests Linkage at 5P, 14Q, and 17P

Jouke-Jan Hottenga; John B. Whitfield; Danielle Posthuma; Gonneke Willemsen; Eco J.C. de Geus; Nicholas G. Martin; Dorret I. Boomsma

From the Department of Biological Psychology and the Center for Neurogenomics and Clinical Research (J.-J.H., D.P., G.W., E.J.C.d.G., D.I.B.), Vrije Universiteit, Amsterdam, The Netherlands; and the Genetic Epidemiology Laboratory (J.B.W., N.G.M.), Queensland Institute of Medical Research, Brisbane, Australia.

Correspondence to Jouke-Jan Hottenga, Van der Boechorststraat 1, 1081 BT Amsterdam, The Netherlands. E-mail jj.hottenga{at}psy.vu.nl

Large-scale studies estimate the heritability of blood pressure at 50%. We carried out a genome-wide linkage analysis to search for chromosomal loci that might explain this heritability using longitudinal, multiple measures of systolic and diastolic blood pressure obtained in sibling pairs and dizygotic twin pairs from 2 countries (a total of 286 pairs from Australia and 636 pairs from the Netherlands). These pairs and a large number of their parents were genotyped with microsatellite markers. Multivariate linkage analysis of the combined data of both countries, using a variance components approach, showed suggestive linkage for diastolic blood pressure on chromosomes 5p13.1 (logarithm of odds score: 2.48), 14q12 (logarithm of odds score: 2.40) and 17q24.3 (logarithm of odds score: 2.36). The highest logarithm of odds score of 1.21 for systolic blood pressure was observed on chromosome 13q34. These results replicate earlier findings and add to a slowly emerging picture of multiple loci contributing to quantitative blood pressure variation.

Key Words: epidemiology • twin study • blood pressure • genetic linkage • longitudinal studies • candidate genes

This article has been cited by other articles:

				P.-a. B. Shih and D. T. O'Connor Hereditary Determinants of Human Hypertension: Strategies in the Setting of Genetic Complexity Hypertension, June 1, 2008; 51(6): 1456 - 1464. [Full Text] [PDF]