This Article Full Text Full Text (PDF) Data Supplement All Versions of this Article: 49/6/1342    most recent HYPERTENSIONAHA.107.087213v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Carlström, M. Articles by Persson, A. E. G. Search for Related Content PubMed PubMed Citation Articles by Carlström, M. Articles by Persson, A. E. G. Related Collections Cardio-renal physiology/pathophysiology Animal models of human disease Other hypertension Hypertrophy

(Hypertension. 2007;49:1342.)
© 2007 American Heart Association, Inc.

Original Articles

Uninephrectomy in Young Age or Chronic Salt Loading Causes Salt-Sensitive Hypertension in Adult Rats

Mattias Carlström; Johan Sällström; Ole Skøtt; Erik Larsson; A. Erik G. Persson

From the Department of Medical Cell Biology (M.C., J.S., A.E.G.P.), Division of Integrative Physiology, and the Department of Genetics and Pathology (E.L.), Uppsala University, Uppsala, Sweden; and the Department of Physiology and Pharmacology (O.S.), University of Southern Denmark, Odense, Denmark.

Correspondence to A. Erik G. Persson, Department of Medical Cell Biology, Biomedical Center, Box 571, SE-75123 Uppsala, Sweden. E-mail Erik.Persson{at}mcb.uu.se

The importance of nephron endowment and salt intake for the development of hypertension is under debate. The present study was designed to investigate whether reduced nephron number, after completion of nephrogenesis, or chronic salt loading causes renal injury and salt-sensitive hypertension in adulthood. Rats were operated at 3 weeks of age (after completed nephrogenesis) and then subjected to either normal or high-salt diets for 6 to 8 weeks. Four different experimental groups were used: sham-operated animals raised with normal-salt diet (controls) or high-salt diet (HS) and uninephrectomized animals raised with normal-salt diet (UNX) or high-salt diet (UNX+HS). In the adult animals, renal and cardiovascular functions were evaluated and blood pressure recorded telemetrically under different sodium conditions (normal, high, and low). Hypertension was present in UNX+HS (122±9 mm Hg), UNX (101±3 mm Hg), and HS (96±1 mm Hg) groups on normal-salt diets compared with the controls (84±2 mm Hg), and the blood pressure was salt sensitive (high- versus normal-salt diet; 23±3, 9±2, 7±2, and 1±1 mm Hg, respectively). The hypertensive groups (UNX+HS, UNX, and HS) had increased diuresis and reduced ability to concentrate urine. The glomerular filtration rate (milliliters per minute) in anesthetized rats was reduced in the UNX+HS (2.36±0.30) and UNX animals (2.00±0.31) compared with both HS animals (3.55±0.45) and controls (3.01±0.35). Hypertensive groups displayed reduced plasma renin concentrations during high sodium conditions and hypertrophic kidneys and hearts with various degrees of histopathologic changes. In conclusion, at a young age after completed nephrogenesis, uninephrectomy or chronic salt loading causes renal and cardiovascular injury with salt-sensitive hypertension.

Key Words: blood pressure • cardiovascular diseases • fibrosis • glomerular filtration rate • hypertension renal • nephrectomy • sodium dietary

This article has been cited by other articles:

				J. S. Amaral, M. J. Pinho, and P. Soares-da-Silva Regulation of amino acid transporters in the rat remnant kidney Nephrol. Dial. Transplant., July 1, 2009; 24(7): 2058 - 2067. [Abstract] [Full Text] [PDF]

				M. Carlstrom, R. D. Brown, J. Sallstrom, E. Larsson, M. Zilmer, S. Zabihi, U. J. Eriksson, and A. E. G. Persson SOD1 deficiency causes salt sensitivity and aggravates hypertension in hydronephrosis Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2009; 297(1): R82 - R92. [Abstract] [Full Text] [PDF]

				M. Carlstrom, R. D. Brown, J. Edlund, J. Sallstrom, E. Larsson, T. Teerlink, F. Palm, N. Wahlin, and A. E. G. Persson Role of nitric oxide deficiency in the development of hypertension in hydronephrotic animals Am J Physiol Renal Physiol, February 1, 2008; 294(2): F362 - F370. [Abstract] [Full Text] [PDF]