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(Hypertension. 2007;49:1448.)
© 2007 American Heart Association, Inc.

Original Articles

Adiponectin Level and Left Ventricular Hypertrophy in Japanese Men

Hirotsugu Mitsuhashi; Hiroshi Yatsuya; Koji Tamakoshi; Kunihiro Matsushita; Rei Otsuka; Keiko Wada; Kaichiro Sugiura; Seiko Takefuji; Yo Hotta; Takahisa Kondo; Toyoaki Murohara; Hideaki Toyoshima

From the Department of Public Health/Health Information Dynamics (H.M., H.Y., K.T., K.M., R.O., K.W., K.S., S.T., Y.H., H.T.), Nagoya University Graduate School of Medicine, Nagoya, Japan; the Department of Cardiology (H.M., K.M., K.S., T.K., T.M.), Nagoya University Graduate School of Medicine, Nagoya, Japan; and the Department of Endocrinology (S.T., Y.H.), Nagoya University Graduate School of Medicine, Nagoya, Japan.

Correspondence to Hideaki Toyoshima, Department of Public Health/Health Information Dynamics, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan. E-mail hirot{at}med.nagoya-u.ac.jp

A recent study has demonstrated that adiponectin inhibited hypertrophic signaling in the myocardium of mice, implying that a decrease in the blood adiponectin level could cause cardiac muscle hypertrophy. We hypothesized that a relationship might exist between the serum adiponectin level and electrocardiographically diagnosed left ventricular hypertrophy (ECG-LVH), and we examined this hypothesis by epidemiological study of 2839 Japanese male workers who were not taking medications for hypertension. ECG-LVH was defined as meeting Sokolow–Lyon voltage criteria and/or Cornell voltage-duration product. The subjects were categorized by tertiles of serum adiponectin level, and a multivariate logistic regression analysis was conducted relating left ventricular hypertrophy to adiponectin tertiles adjusting for potential confounding factors. Prevalence of ECG-LVH in the studied sample was 16.7%. Adiponectin ranged from 1.0 to 5.0 µg/mL in the lowest category and from 7.4 to 30.6 µg/mL in the highest. Compared with subjects in the highest adiponectin category, those in the lowest one had a significantly higher prevalence of ECG-LVH independent of age, body mass index, and systolic blood pressure with an odds ratio of 1.50 and a 95% CI of 1.16 to 1.94. Further adjustment for high-density lipoprotein cholesterol, triglyceride, and insulin resistance did not change the association (odds ratio: 1.68; 95% CI: 1.28 to 2.21; P<0.001). Similar results were obtained when different criteria for ECG-LVH were used or when subjects were stratified by blood pressure or body mass index. Adiponectin concentration was inversely and independently associated with ECG-LVH in Japanese men.

Key Words: adiponectin • left ventricular hypertrophy • electrocardiography • epidemiologic study • Japanese