Hypertension, Vol 5, 8-16, Copyright © 1983 by American Heart Association
VH Gattone 2d, AP Evan, LR Willis and FC Luft
We conducted morphometric studies on the afferent arteriole of spontaneous
hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats to gain a better
understanding of its changes with the development of hypertension.
Differences may be related to the SHRs' increased renal vascular
resistance. Methacrylate vascular casts were made of the renal vasculature
after perfusion fixation with glutaraldehyde. These vascular casts were
then examined and measurements made with the scanning electron microscope.
Results from this examination of the scanning electron microscope
demonstrated a smaller afferent arteriolar diameter in the SHR, compared to
the WKY, for both the inner and outer cortical glomeruli. This difference
was seen in the 6-week-old SHR, prior to a statistically different blood
pressure from the WKY controls, as well as in the 12-week-old hypertensive
SHR. However, this afferent diameter difference between rat strains was
more pronounced in rats at 12 weeks of age. The tapering of the afferent
arteriole (difference between proximal and distal afferent diameters) was
greater in the 12-week-old SHR than in the age-matched WKY or 6-week-old
SHR. We conclude that the smaller caliber afferent arterioles of the SHR
may predispose and play a role in the pathogenesis of the subsequent
hypertension. The increased afferent arteriolar tapering seen in the
hypertensive SHR relates to the already present increased blood pressure.
Wall thickness/radius ratios are not different between rat strains (SHR and
WKY) at either 6 or 12 weeks of age. These results suggest increased
vascular constriction or hypoplastic vessels as the cause of the smaller
caliber vessels in the SHR rather than increased wall thickness.
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Renal afferent arteriole in the spontaneously hypertensive rat
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