Hypertension, Vol 5, 86-99, Copyright © 1983 by American Heart Association
DS Goldstein
Of 78 comparative studies of plasma catecholamines in patients with
essential hypertension and in normotensive controls, most reported higher
catecholamine levels in the hypertensives, although only about 40% of the
studies were positive (reporting statistically significant
hypertensive-normotensive differences). Although there was dramatic
variability in catecholamine values within and across studies, virtually
all studies of norepinephrine in young, consistently hypertensive patients
were positive. The likelihood that a study was positive with respect to
norepinephrine was independent of the likelihood with respect to
epinephrine, so that total catecholamine values, or else the sum of
norepinephrine plus epinephrine, differentiated hypertensives from
normotensives to a greater extent than levels of either substance alone.
The preponderance of literature on the subject supports the hypothesis that
increased plasma catecholamine concentrations occur in some patients with
essential hypertension. Elevated plasma norepinephrine in relatively young,
established hypertensive patients is consistent with a pathophysiologic
role for increased sympathetic neural activity in this subgroup.
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