Hypertension, Vol 5, 346-352, Copyright © 1983 by American Heart Association
ER Gonzalez, AJ Krieger and HN Sapru
The role of central nervous system in the resetting of baroreflex was
investigated in 5-month-old spontaneously hypertensive rats (SHR) of
Okamoto strain. Age-matched Wistar-Kyoto (WKY) rats were used as
normotensive controls. The aortic nerves, which in the rat, contain few or
no chemoreceptor fibers, were stimulated electrically using a wide range of
stimulus frequencies. The depressor responses (expressed as percent
decrease in blood pressure as compared to its blood pressure value prior to
aortic nerve stimulation) produced by these stimulations were significantly
smaller in SHR than those in WKY. In another series of experiments, changes
in the efferent limb of the baroreflex arc (i.e., greater splanchnic nerve
activity) in response to stimulation of the baroreceptor afferents in the
aortic nerve were recorded. Inhibition of the greater splanchnic nerve
activity due to aortic nerve stimulation was found to be significantly
smaller in SHR than in the WKY. Control sympathetic nerve activity was
greater in SHR than in WKY. These results suggest that the central
bulbospinal nervous system may be another site for resetting of baroreflex
in hypertension.
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Central resetting of baroreflex in the spontaneously hypertensive rat
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