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Hypertension, Vol 5, 579-583, Copyright © 1983 by American Heart Association

ARTICLES

Antihypertensive effectiveness of intravenous labetalol in accelerated hypertension

WB Smith, GG Clifton, WM O'Neill Jr and JD Wallin

Labetalol, an antihypertensive agent that blocks both beta- and alpha- adrenergic receptors, was administered intravenously to 19 patients with accelerated hypertension who required rapid lowering of blood pressure. Systolic blood pressure was lowered from 209 +/- 4 to 143 +/- 2 mm Hg; diastolic blood pressure was reduced from 140 +/- 2 to 93 +/- 2 mm Hg. Side-effects were minimal and included nausea, epigastric burning, rhinorrhea, and premature ventricular contractions. One patient became hypotensive and required treatment. Overall, the study demonstrates labetalol to be a safe and effective agent for the emergency lowering of blood pressure, with demonstrated results comparable to other parenteral agents.

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