This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Izzo, J. Search for Related Content PubMed PubMed Citation Articles by Izzo, J., Jr

Hypertension, Vol 5, 787-789, Copyright © 1983 by American Heart Association

ARTICLES

Cardiovascular hormonal effects of circulating norepinephrine

J Izzo Jr

The hormonal effects of circulating norepinephrine (NE) were evaluated with two-step NE infusion studies in normal volunteers. At an infusion rate that increased plasma NE 2.5-fold (approximately equivalent to the change from supine to upright posture), there were small but consistent increases in diastolic pressure (+5 mm Hg) and plasma renin activity (+13%). At the high extreme of the physiologic range (a 9-fold increase over supine basal), circulating NE caused major changes in blood pressure (+22/15 mm Hg), heart rate (-7 bpm), and plasma renin activity (+67%). Thus, at physiologic concentrations, circulating NE should be considered to be a cardiovascular hormone as well as an index of sympathetic nervous activity.

This article has been cited by other articles:

				M. P. Tulppo, H. V. Huikuri, E. Tutungi, D. S. Kimmerly, A. W. Gelb, R. L. Hughson, T. H. Makikallio, and J. Kevin Shoemaker Feedback effects of circulating norepinephrine on sympathetic outflow in healthy subjects Am J Physiol Heart Circ Physiol, February 1, 2005; 288(2): H710 - H715. [Abstract] [Full Text] [PDF]