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Hypertension, Vol 5, 881-886, Copyright © 1983 by American Heart Association
M Konishi and C Su
The possible role of endothelium in the vascular responses to vasodilator
drugs was studied in relation to experimental hypertension. Short ring
segments of the thoracic aorta and femoral artery were removed from
spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY)
rats. They were rubbed on the intimal surface to destruct endothelial cells
or unrubbed, and bathed in Krebs-bicarbonate solution for isometric
recording of contractile and relaxant responses. The relaxant response to
acetylcholine was abolished by rubbing all arteries tested. Rubbing also
significantly attenuated the relaxation induced by adenosine in the SHR
aorta and SHR and WKY femoral artery, and attenuated the relaxation by
isoproterenol in the SHR femoral artery. In contrast, contractile response
to norepinephrine was augmented by intimal surface rubbing in all arteries
except the aorta of WKY. It is suggested that an endothelial compensatory
mechanism develops to offset the diminished relaxant and/or increased
contractile responsiveness of smooth muscle cells in the hypertensive rat
arteries.
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