This Article Free upon publication Full Text Full Text (PDF) All Versions of this Article: 51/4/1109    most recent HYPERTENSIONAHA.107.107474v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Gerdts, E. Articles by Devereux, R. B. Search for Related Content PubMed PubMed Citation Articles by Gerdts, E. Articles by Devereux, R. B. Related Collections Hypertrophy Clinical Studies Echocardiography

(Hypertension. 2008;51:1109.)
© 2008 American Heart Association, Inc.

Go Red Original Articles

Gender Differences in Left Ventricular Structure and Function During Antihypertensive Treatment

The Losartan Intervention for Endpoint Reduction in Hypertension Study

Eva Gerdts; Peter M. Okin; Giovanni de Simone; Dana Cramariuc; Kristian Wachtell; Kurt Boman; Richard B. Devereux

From the Institute of Medicine (E.G., D.C.), University of Bergen, Bergen, Norway; Department of Heart Disease (E.G., D.C.), Haukeland University Hospital, Bergen, Norway; Department of Medicine (P.M.O., R.B.D.), Weill Medical College of Cornell University, New York, NY; Department of Clinical and Experimental Medicine (G.d.S.), Federico II University Hospital, Naples, Italy; Heart Center (K.W.), Rigshospitalet, Copenhagen, Denmark; and the Department of Medicine (K.B.), Skellefteå Hospital and Umeå University, Skellefteå, Sweden.

Correspondence to Eva Gerdts, Institute of Medicine, University of Bergen, Haukeland University Hospital, N-5021 Bergen, Norway. E-mail gerdtsev{at}online.no

In hypertensive patients with left ventricular hypertrophy, antihypertensive treatment induces changes in left ventricular structure and function. However, less is known about gender differences in this response. Baseline and annual echocardiograms until the end of study or a primary end point occurred were assessed in 863 hypertensive patients with electrocardiographic left ventricular hypertrophy aged 55 to 80 years (mean: 66 years) during 4.8 years of randomized losartan- or atenolol-based treatment in the Losartan Intervention for Endpoint Reduction in Hypertension Echocardiography substudy. Left ventricular hypertrophy was diagnosed as left ventricular mass divided by height^2.7 46.7 g/m^2.7 and 49.2 g/m^2.7 in women and men, respectively, and systolic function as ejection fraction and stress-corrected midwall fractional shortening. Women included more patients with obesity, isolated systolic hypertension, and mitral regurgitation (all P<0.01). Ejection fraction, stress-corrected midwall shortening, and prevalence of left ventricular hypertrophy were higher in women at baseline and at the end of study (all P<0.01). In particular, more women had residual eccentric hypertrophy (47% versus 32%; P<0.01) in spite of similar in-treatment reduction in mean blood pressure. In logistic regression, left ventricular hypertrophy at study end was more common in women (odds ratio: 1.61; 95% CI: 1.16 to 2.26; P<0.01) independent of other significant covariates. In linear regression analyses, female gender also predicted 2% higher mean in-treatment ejection fraction and 2% higher mean stress-corrected midwall shortening (both β=0.07; P<0.01). Hypertensive women in this study retained higher left ventricular ejection fraction and stress-corrected midwall shortening in spite of less hypertrophy regression during long-term antihypertensive treatment.

Key Words: gender • hypertension • systolic function • left ventricular hypertrophy • hypertrophy regression

This article has been cited by other articles:

				L. Zelarayan, A. Renger, C. Noack, M.-P. Zafiriou, C. Gehrke, R. van der Nagel, R. Dietz, L. de Windt, and M. W. Bergmann NF-{kappa}B activation is required for adaptive cardiac hypertrophy Cardiovasc Res, December 1, 2009; 84(3): 416 - 424. [Abstract] [Full Text] [PDF]

				E. Gerdts Left ventricular structure in different types of chronic pressure overload Eur. Heart J. Suppl., July 1, 2008; 10(suppl_E): E23 - E30. [Abstract] [Full Text] [PDF]

				E. Agabiti-Rosei and M. Salvetti Gender Differences in the Regression of Electrocardiographic Left Ventricular Hypertrophy During Antihypertensive Therapy Hypertension, July 1, 2008; 52(1): 59 - 60. [Full Text] [PDF]

				I. Os, R. B. Devereux, and P. M. Okin Response to Gender Differences in Left Ventricular Hypertrophy Regression Hypertension, June 1, 2008; 51(6): e59 - e59. [Full Text] [PDF]