This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Ganguly, A. Articles by Fineberg, N. S. Search for Related Content PubMed PubMed Citation Articles by Ganguly, A. Articles by Fineberg, N. S.

Hypertension, Vol 6, 563-567, Copyright © 1984 by American Heart Association

ARTICLES

Adrenal steroid responses to ACTH in glucocorticoid-suppressible aldosteronism

A Ganguly, MH Weinberger, GP Guthrie and NS Fineberg

To investigate adrenal responses to adrenocorticotrophin (ACTH), we infused graded doses of ACTH (1.25 to 20.0 mIU/30 minutes) in normal subjects, patients with low-renin essential hypertension (LREH), primary aldosteronism (PA), and glucocorticoid-suppressible hyperaldosteronism (GSH). Plasma aldosterone, cortisol, corticosterone, and 18-hydroxycorticosterone were measured. The results revealed a greater increase in the plasma aldosterone and 18-hydroxycorticosterone levels evoked by ACTH in the GSH group than in any other group, which suggested enhanced responsiveness of the aldosterone-producing cells to ACTH and a probable adrenal abnormality.

This article has been cited by other articles:

				W. R. Litchfield, C. Coolidge, P. Silva, R. P. Lifton, F. Fallo, G. H. Williams, and R. G. Dluhy Impaired Potassium-Stimulated Aldosterone Production: A Possible Explanation for Normokalemic Glucocorticoid-Remediable Aldosteronism J. Clin. Endocrinol. Metab., May 1, 1997; 82(5): 1507 - 1510. [Abstract] [Full Text] [PDF]

				P. C. White Inherited Forms of Mineralocorticoid Hypertension Hypertension, December 1, 1996; 28(6): 927 - 936. [Abstract] [Full Text]