Hypertension, Vol 6, 597-603, Copyright © 1984 by American Heart Association
LJ Field, RA McGowan, DP Dickinson and KW Gross
The Ren-1 locus of mice encodes the protease renin, which with converting
enzyme processes angiotensinogen to the potent vasopressor angiotensin II.
Some strains of mice appear to carry a duplication of the renin structural
gene (Ren-2) near the Ren-1 locus. Strains with the gene duplication can
exhibit as much as 100-fold higher levels of submaxillary gland renin
compared to strains with a single gene copy. In contrast, kidney renin
levels appear to be unaffected by the gene duplication. Sequence analysis
of a 319 bp renin cDNA recombinant isolated from a kidney library from the
two-gene strain DBA/2Ha corresponds to a transcript of the Ren-1 gene.
Moreover, a single base substitution of A for G at residue #996 in the
kidney renin mRNA creates a potential glycosylation recognition site that
may, in part, account for the differential glycosylation of kidney and
submaxillary gland renins. In addition, our tissue surveys indicate that
mature mRNAs from the Ren loci are detectable in adrenal gland and testes,
as well as sublingual and parotid salivary glands, and reveal length
variation for the renin transcripts in at least the submaxillary gland.
ARTICLES
Tissue and gene specificity of mouse renin expression
This article has been cited by other articles:
 |
|
 |
|
  M. Paul, A. Poyan Mehr, and R. Kreutz Physiology of local Renin-Angiotensin systems. Physiol Rev, July 1, 2006; 86(3): 747 - 803. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Hartner, N. Cordasic, B. Klanke, R. Veelken, and K. F. Hilgers Strain differences in the development of hypertension and glomerular lesions induced by deoxycorticosterone acetate salt in mice Nephrol. Dial. Transplant., October 1, 2003; 18(10): 1999 - 2004. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Fuchs, S. Germain, J. Philippe, P. Corvol, and F. Pinet Expression of Renin in Large Arteries Outside the Kidney Revealed by Human Renin Promoter/LacZ Transgenic Mouse Am. J. Pathol., August 1, 2002; 161(2): 717 - 725. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Xia, H. Wen, H. R. Prashner, R. Chen, T. Inagami, D. F. Catanzaro, and R. E. Kellems Pregnancy-Induced Changes in Renin Gene Expression in Mice Biol Reprod, January 1, 2002; 66(1): 135 - 143. [Abstract] [Full Text]
|
|
|
|
 |
|
 W. C. De Mello Intracellular Angiotensin II Regulates the Inward Calcium Current in Cardiac Myocytes Hypertension, December 1, 1998; 32(6): 976 - 982. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Petrovic, C. M. Kane, C. D. Sigmund, and K. W. Gross Downregulation of Renin Gene Expression by Interleukin-1 Hypertension, August 1, 1997; 30(2): 230 - 235. [Abstract] [Full Text]
|
|
|
|
 |
|
 N. Petrovic, T. A. Black, J. R. Fabian, C. Kane, C. A. Jones, J. A. Loudon, J. P. Abonia, C. D. Sigmund, and K. W. Gross Role of Proximal Promoter Elements in Regulation of Renin Gene Transcription J. Biol. Chem., September 13, 1996; 271(37): 22499 - 22505. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. C. De Mello Renin-Angiotensin System and Cell Communication in the Failing Heart Hypertension, June 1, 1996; 27(6): 1267 - 1272. [Abstract] [Full Text]
|
|
|
|
|
|
N. Tomita, R. Morishita, J. Higaki, M. Aoki, Y. Nakamura, H. Mikami, A. Fukamizu, K. Murakami, Y. Kaneda, and T. Ogihara Transient Decrease in High Blood Pressure by In Vivo Transfer of Antisense Oligodeoxynucleotides Against Rat Angiotensinogen Hypertension, July 1, 1995; 26(1): 131 - 136. [Abstract] [Full Text]
|
|
|
|
 |
|
 G. Nemeth, J. R. Pepperell, Y. Yamada, A. Palumbo, and F. Naftolin The Basis and Evidence of a Role for the Ovarian Renin-Angiotensin System in Health and Disease Reproductive Sciences, April 1, 1994; 1(2): 118 - 127. [Abstract] [PDF]
|
|
|
|
 |
|
 J. Rapp, S. Wang, and H Dene A genetic polymorphism in the renin gene of Dahl rats cosegregates with blood pressure Science, January 27, 1989; 243(4890): 542 - 544. [Abstract] [PDF]
|
|