This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by London, G. M. Articles by Simon, A. C. Search for Related Content PubMed PubMed Citation Articles by London, G. M. Articles by Simon, A. C.

Hypertension, Vol 6, 743-754, Copyright © 1984 by American Heart Association

ARTICLES

Renal and systemic hemodynamics in sustained essential hypertension

GM London, ME Safar, JE Sassard, JA Levenson and AC Simon

Cardiac output (CO), renal blood flow (RBF), calf blood flow (CBF), and hepatic blood flow (HBF), glomerular filtration rate (GFR), and dopamine beta hydroxylase (D beta H) activity were studied in 198 men (67 normotensive controls and 131 hypertensive patients) of the same age with sustained uncomplicated essential hypertension. In the hypertensive men, the RBF and the RBF/CO ratio were significantly decreased (p less than 0.001). The RBF and RBF/CO ratio were negatively correlated with age (p less than 0.01), blood pressure (p less than 0.01), and D beta H activity (p less than 0.01). None of these relationships were observed with CBF and HBF. The observed decreases in RBF and the RBF/CO ratio in hypertensive men were reversed after administration of clonidine and alpha-methyldopa (p less than 0.01), but not after administration of propranolol. The study provides evidence that the reduction of renal perfusion in essential hypertension is partly reversible and related to an abnormality in the adrenergic system control.

This article has been cited by other articles:

				R. Zeltner, C. Delles, M. Schneider, W. Siffert, and R. E. Schmieder G-Protein {beta}3 Subunit Gene (GNB3) 825T Allele Is Associated With Enhanced Renal Perfusion in Early Hypertension Hypertension, March 1, 2001; 37(3): 882 - 886. [Abstract] [Full Text] [PDF]

				F. H. Messerli, E. Grossman, and U. Goldbourt Are {beta}-Blockers Efficacious as First-line Therapy for Hypertension in the Elderly?: A Systematic Review JAMA, June 17, 1998; 279(23): 1903 - 1907. [Abstract] [Full Text] [PDF]