This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Baruch, D. Articles by Menard, J. Search for Related Content PubMed PubMed Citation Articles by Baruch, D. Articles by Menard, J.

Hypertension, Vol 6, 760-766, Copyright © 1984 by American Heart Association

ARTICLES

Diagnosis and treatment of renin-secreting tumors. Report of three cases

D Baruch, P Corvol, F Alhenc-Gelas, MA Dufloux, TT Guyenne, JC Gaux, A Raynaud, JM Brisset, JM Duclos and J Menard

During the past 10 years, we have found renin-secreting renal juxtaglomerular cell tumors in three hypertensive patients (two women, one man, aged 22, 69, and 21 years, respectively). The major chemical and biological findings revealed the association of severe hypertension with hypokalemia and increased plasma renin activity and plasma aldosterone. The diagnosis of such tumors is difficult, and two of the three patients were followed up for four and five years respectively before undergoing surgery. The pharmacological blockade of the renin system by various agents (beta-blockers, angiotensin II antagonists, and captopril) and its effects on blood pressure and plasma renin activity proved to be unreliable. Renal venous catheterization for renin measurements failed to provide adequate localization of the tumor. Direct radioimmunoassay, however, showed the total plasma renin to be markedly elevated. In addition, renal arteriography showed an avascular area corresponding to the renin-secreting tumor in each of the three patients. All three patients were cured of hypertension and hypokalemia by excision of the tumor.

This article has been cited by other articles:

				L. Balu, J.-M. Gasc, L. Boccon-Gibod, P. De Vries, P. Blanc, V. Guigonis, G. Deschenes, A. Bensman, and T. Ulinski Arterial hypertension and ovarian tumour in a girl: what is the link? Nephrol. Dial. Transplant., January 1, 2005; 20(1): 231 - 234. [Full Text] [PDF]

				C. H. Kim, Y. W. Park, N. G. Ordonez, A. G. Ayala, J. F. Burroughs, and J. Y. Ro Juxtaglomerular Cell Tumor of the Kidney: Case Report with Immunohistochemical and Electron Microscopic Investigations and Review of the Literature International Journal of Surgical Pathology, April 1, 1999; 7(2): 115 - 123. [Abstract] [PDF]

				M. Agarwal, K. L. Lynn, A. M. Richards, and M. G. Nicholls Hyponatremic-Hypertensive Syndrome With Renal Ischemia : An Underrecognized Disorder Hypertension, April 1, 1999; 33(4): 1020 - 1024. [Abstract] [Full Text] [PDF]