This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Martin, A. F. Articles by McMahon, E. G. Search for Related Content PubMed PubMed Citation Articles by Martin, A. F. Articles by McMahon, E. G.

Hypertension, Vol 8, 128-132, Copyright © 1986 by American Heart Association

ARTICLES

Isomyosin transitions in ventricles of aldosterone-salt hypertensive rats

AF Martin, RJ Paul and EG McMahon

The isomyosin composition in left and right ventricles from aldosterone- salt-treated hypertensive rats and from vehicle-infused and aldosterone- infused normotensive control rats was compared. A significant incremental increase (20%) in the percentage of V3 isomyosin and parallel decrease in the percentage of V1 isomyosin occurred in both left and right ventricles from aldosterone-salt-treated animals compared with those in normotensive vehicle-infused controls. No change in the ventricular isomyosin distribution was observed in animals infused with aldosterone without salt, which indicates that aldosterone does not directly affect the ventricular isomyosin composition. The changes in left ventricular isomyosin composition were accompanied by significant left ventricular hypertrophy (38%; p less than 0.05), whereas no hypertrophy was observed in the right ventricle. Plasma thyroxine levels were significantly lower in aldosterone-salt-treated rats (3.7 +/- 0.6 micrograms/dl; p less than 0.05) than in normotensive vehicle-infused (6.0 +/- 0.7 micrograms/dl) or aldosterone-infused (6.7 +/- 0.3 micrograms/dl) controls. These results indicate that factors such as alterations in thyroid status or a volume overload component of this hypertensive model, in addition to increased systolic blood pressure, may contribute to a biventricular shift in isomyosin composition in the aldosterone-salt model of hypertension.

This article has been cited by other articles:

				S. D. Blank, J. A. Lahorra, R. S. McDonald, A. G. Denenberg, J. S. Titus, D. F. Torchiana, W. M. Daggett, and G. A. Geffin Superior Recovery of Hypertrophied Rat Myocardium After Cardioplegic Arrest Ann. Thorac. Surg., February 1, 1998; 65(2): 390 - 396. [Abstract] [Full Text] [PDF]

				V. Robert, J.-S. Silvestre, D. Charlemagne, A. Sabri, P. Trouve, M. Wassef, B. Swynghedauw, and C. Delcayre Biological Determinants of Aldosterone-Induced Cardiac Fibrosis in Rats Hypertension, December 1, 1995; 26(6): 971 - 978. [Abstract] [Full Text]