Hypertension, Vol 8, 344-348, Copyright © 1986 by American Heart Association
TF Luscher and PM Vanhoutte
To study the mechanism of decreased endothelium-dependent relaxations in
spontaneously hypertensive rats (SHR), rings of thoracic aorta with and
without endothelium were taken from age-matched male SHR and normotensive
Wistar-Kyoto rats (WKY) and suspended for isometric tension recording.
Acetylcholine caused endothelium-dependent contractions in quiescent rings
from SHR but not in those from WKY. These contractions were inhibited by
atropine but not by hexamethonium and were prevented by inhibitors of
phospholipase A2 or cyclooxygenase but not by inhibitors of prostacyclin
synthetase, thromboxane synthetase, or leukotriene synthetase.
Prostaglandin D2, E1, E2, and F2 alpha caused concentration-dependent
contractions in rings without endothelium from both SHR and WKY; the
responses to the highest concentration (10(-5) M) of the individual
prostaglandins were comparable in both strains. Endothelium-dependent
relaxations evoked by high but not by low concentrations of acetylcholine
were significantly depressed in SHR as compared with those in WKY (p less
than 0.05). Indomethacin normalized endothelium-dependent relaxations in
SHR. Thus, acetylcholine can activate muscarinic receptors that evoke
endothelium- dependent contractions in the aorta of SHR but not in that of
WKY. The contraction probably is mediated by a cyclooxygenase product(s)
other than prostacyclin or thromboxane A2. The reduced
endothelium-dependent relaxations to acetylcholine in the SHR probably are
not due to a decreased release of endothelium-derived relaxing factor(s)
but to the simultaneous release of endothelium-derived contracting
substance(s).
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Endothelium-dependent contractions to acetylcholine in the aorta of the spontaneously hypertensive rat
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E. D. Frohlich Influence of Nitric Oxide and Angiotensin II on Renal Involvement in Hypertension Hypertension, January 1, 1997; 29(1): 188 - 193. [Abstract] [Full Text] [PDF]
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H. Hayakawa and L. Raij The Link Among Nitric Oxide Synthase Activity, Endothelial Function, and Aortic and Ventricular Hypertrophy in Hypertension Hypertension, January 1, 1997; 29(1): 235 - 241. [Abstract] [Full Text] [PDF]
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S. Taddei, A. Virdis, L. Ghiadoni, A. Magagna, and A. Salvetti Cyclooxygenase Inhibition Restores Nitric Oxide Activity in Essential Hypertension Hypertension, January 1, 1997; 29(1): 274 - 279. [Abstract] [Full Text] [PDF]
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N. Hutri-Kahonen, M. Kahonen, J.-P. Tolvanen, W. Xiumin, K. Sallinen, and I. Porsti Ramipril therapy improves arterial dilation in experimental hypertension Cardiovasc Res, January 1, 1997; 33(1): 188 - 195. [Abstract] [Full Text] [PDF]
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Y. Dohi, M. Kojima, and K. Sato Endothelial Modulation of Contractile Responses in Arteries From Hypertensive Rats Hypertension, November 1, 1996; 28(5): 732 - 737. [Abstract] [Full Text]
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Y. Erlich and T. Rosenthal Contribution of Nitric Oxide to the Beneficial Effects of Enalapril in the Fructose-Induced Hyperinsulinemic Rat Hypertension, November 1, 1996; 28(5): 754 - 757. [Abstract] [Full Text]
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R. J. Baines, C. Brown, L. L. Ng, and M. R. Boarder Angiotensin II–Stimulated Phospholipase C Responses of Two Vascular Smooth Muscle–Derived Cell Lines: Role of Cyclic GMP Hypertension, November 1, 1996; 28(5): 772 - 778. [Abstract] [Full Text]
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S. Taddei, A. Virdis, L. Ghiadoni, P. Mattei, I. Sudano, G. Bernini, S. Pinto, and A. Salvetti Menopause Is Associated With Endothelial Dysfunction in Women Hypertension, October 1, 1996; 28(4): 576 - 582. [Abstract] [Full Text]
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P. Gohlke, W. Linz, B. A. Scholkens, G. Wiemer, and T. Unger Cardiac and Vascular Effects of Long-term Losartan Treatment in Stroke-Prone Spontaneously Hypertensive Rats Hypertension, September 1, 1996; 28(3): 397 - 402. [Abstract] [Full Text]
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K. Kugiyama, H. Yasue, K. Okumura, H. Ogawa, K. Fujimoto, K. Nakao, M. Yoshimura, T. Motoyama, Y. Inobe, and H. Kawano Nitric Oxide Activity Is Deficient in Spasm Arteries of Patients With Coronary Spastic Angina Circulation, August 1, 1996; 94(3): 266 - 272. [Abstract] [Full Text]
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Y. Dohi, M. Kojima, and K. Sato Benidipine Improves Endothelial Function in Renal Resistance Arteries of Hypertensive Rats Hypertension, July 1, 1996; 28(1): 58 - 63. [Abstract] [Full Text]
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R. M. Rapoport and S. P. Williams Role of Prostaglandins in Acetylcholine-Induced Contraction of Aorta From Spontaneously Hypertensive and Wistar-Kyoto Rats Hypertension, July 1, 1996; 28(1): 64 - 75. [Abstract] [Full Text]
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J. Frielingsdorf, C. Seiler, P. Kaufmann, G. Vassalli, T. Suter, and O. M. Hess Normalization of Abnormal Coronary Vasomotion by Calcium Antagonists in Patients With Hypertension Circulation, April 1, 1996; 93(7): 1380 - 1387. [Abstract] [Full Text]
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P. Madeddu, P. P. Parpaglia, V. Anania, N. Glorioso, C. Chao, C. Wang, and J. Chao Sexual Dimorphism of Cardiovascular Responses to Early Blockade of Bradykinin Receptors Hypertension, March 1, 1996; 27(3): 746 - 751. [Abstract] [Full Text]
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H. Takase, P. Moreau, C. F. Kung, E. Nava, and T. F. Luscher Antihypertensive Therapy Prevents Endothelial Dysfunction in Chronic Nitric Oxide Deficiency : Effect of Verapamil and Trandolapril Hypertension, January 1, 1996; 27(1): 25 - 31. [Abstract] [Full Text]
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C. E. Garcia, C. M. Kilcoyne, C. Cardillo, R. O. Cannon III, A. A. Quyyumi, and J. A. Panza Effect of Copper-Zinc Superoxide Dismutase on Endothelium-Dependent Vasodilation in Patients With Essential Hypertension Hypertension, December 1, 1995; 26(6): 863 - 868. [Abstract] [Full Text]
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A. M. Shircore, W. J. Mack, R. H. Selzer, P. L. Lee, S. P. Azen, P. Alaupovic, and H. N. Hodis Compensatory Vascular Changes of Remote Coronary Segments in Response to Lesion Progression as Observed by Sequential Angiography From a Controlled Clinical Trial Circulation, November 1, 1995; 92(9): 2411 - 2418. [Abstract] [Full Text]
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L. Normandin, P. Herve, C. Brink, A. R. Chapelier, P. G. Dartevelle, and G.-M. Mazmanian L-Arginine and Pentoxifylline Attenuate Endothelial Dysfunction After Lung Reperfusion Injury in the Rabbit Ann. Thorac. Surg., September 1, 1995; 60(3): 646 - 650. [Abstract] [Full Text]
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D. D. Heistad, M. L. Armstrong, G. L. Baumbach, and F. M. Faraci Sick Vessel Syndrome : Recovery of Atherosclerotic and Hypertensive Vessels Hypertension, September 1, 1995; 26(3): 509 - 513. [Abstract] [Full Text]
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H. Ono, Y. Ono, and E. D. Frohlich Nitric Oxide Synthase Inhibition in Spontaneously Hypertensive Rats : Systemic, Renal, and Glomerular Hemodynamics Hypertension, August 1, 1995; 26(2): 249 - 255. [Abstract] [Full Text]
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T. A. Bruning, P. C. Chang, M. G.C. Hendriks, P. Vermeij, M. Pfaffendorf, and P. A. van Zwieten In Vivo Characterization of Muscarinic Receptor Subtypes That Mediate Vasodilatation in Patients With Essential Hypertension Hypertension, July 1, 1995; 26(1): 70 - 77. [Abstract] [Full Text]
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T. Ge, H. Hughes, D. C. Junquero, K. K. Wu, P. M. Vanhoutte, and C. M. Boulanger Endothelium-Dependent Contractions Are Associated With Both Augmented Expressionof Prostaglandin H Synthase-1 and Hypersensitivity to Prostaglandin H2in the SHR Aorta Circ. Res., June 1, 1995; 76(6): 1003 - 1010. [Abstract] [Full Text]
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A. V. Chobanian, S. Hope, and P. Brecher Dissociation Between the Antiatherosclerotic Effect of Trandolapril and Suppression of Serum and Aortic Angiotensin-Converting Enzyme Activity in the Watanabe Heritable Hyperlipidemic Rabbit Hypertension, June 1, 1995; 25(6): 1306 - 1310. [Abstract] [Full Text]
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E. Nava, G. Noll, and T. F. Luscher Increased Activity of Constitutive Nitric Oxide Synthase in Cardiac Endothelium in Spontaneous Hypertension Circulation, May 1, 1995; 91(9): 2310 - 2313. [Abstract] [Full Text]
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M.R. Tschudi and T.F. Luscher Age and Hypertension Differently Affect Coronary Contractions to Endothelin-1, Serotonin, and Angiotensins Circulation, May 1, 1995; 91(9): 2415 - 2422. [Abstract] [Full Text]
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S. Taddei, A. Virdis, P. Mattei, L. Ghiadoni, A. Gennari, C. B. Fasolo, I. Sudano, and A. Salvetti Aging and Endothelial Function in Normotensive Subjects and Patients With Essential Hypertension Circulation, April 1, 1995; 91(7): 1981 - 1987. [Abstract] [Full Text]
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