Hypertension, Vol 8, 438-443, Copyright © 1986 by American Heart Association
RP Shannon, JY Wei, RM Rosa, FH Epstein and JW Rowe
To test the hypothesis that normal age-related limitations in
cardiovascular homeostasis may become clinically significant under stress,
the cardiovascular response to postural change was assessed in six young
and six old healthy subjects before and after modest diuretic- induced
sodium depletion. Before diuresis, systolic blood pressure was maintained
(from 110 +/- 4 to 113 +/- 6 mm Hg) while heart rate increased 22% (from 67
+/- 2 to 82 +/- 5 beats/min) at 3 minutes after 60-degree upright tilt in
young subjects. After a significant diuretic- induced weight reduction and
natriuresis, the young again maintained systolic blood pressure (from 110
+/- 4 to 110 +/- 6 mm Hg) and increased heart rate 49% (from 68 +/- 2 to
101 +/- 5 beats/min; p less than 0.05, compared with prediuresis values) in
response to the same postural stimulus. During the prediuresis tilt, the
older subjects showed no change in systolic blood pressure (from 132 +/- 4
to 134 +/- 6 mm Hg) and a 9% increase in heart rate (from 68 +/- 3 to 74
+/- 2 beats/min). After a similar significant weight reduction and sodium
loss, the older subjects showed a significant reduction in systolic blood
pressure (from 132 +/- 6 to 108 +/- 6 mm Hg; p less than 0.05) and a 17%
increase in heart rate (from 69 +/- 4 to 81 +/- 3 beats/min; p less than
0.05) during tilt compared with values in young subjects. Three of six
elderly subjects noted postural symptoms. These results suggest that,
although the healthy old may appear well compensated under optimal
conditions, decreased cardiovascular reserve renders them susceptible to
postural change following mild sodium depletion.
ARTICLES
The effect of age and sodium depletion on cardiovascular response to orthostasis
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