This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Limas, C. Articles by Limas, C. J. Search for Related Content PubMed PubMed Citation Articles by Limas, C. Articles by Limas, C. J.

Hypertension, Vol 8, 566-571, Copyright © 1986 by American Heart Association

ARTICLES

Up-regulation of renal prostaglandin receptors in genetic salt- dependent hypertension

C Limas and CJ Limas

Development of hypertension in Dahl salt-sensitive rats (DS) is accompanied by reduced renomedullary prostaglandin synthesis, which may be responsible for their lower natriuretic capacity. To examine the changes in renomedullary prostaglandin E2 synthesis, the effects of high (8.0%) and normal (0.6%) NaCl diets were examined in DS and in Dahl salt-resistant rats (DR). In response to an 8.0% NaCl diet, the number of prostaglandin E2 receptors in the renal outer medulla of DR increased (2.97 +/- 0.2 vs 2.18 +/- 0.2 pmol/mg on 0.6% NaCl diet) while no change was noted in their affinities (Kd, 9.5 +/- 0.2 vs 9.4 +/- 0.3 nM). Receptor number and affinity in the renal cortex, inner medulla, and liver of DR were not affected. In contrast, renomedullary receptors of DS had a lower affinity than those of age-matched DR (Kd, 13.9 +/- 0.2 nM on 0.6% NaCl diet and 14.0 +/- 0.3 nM on 8.0% NaCl diet) and did not increase in number after a high salt diet. This apparent inability of DS to modulate prostaglandin receptors may contribute to their susceptibility to salt-induced hypertension.

This article has been cited by other articles:

				T. Yang, S. J. Forrest, N. Stine, Y. Endo, A. Pasumarthy, H. Castrop, S. Aller, J. N. Forrest Jr., J. Schnermann, and J. Briggs Cyclooxygenase cloning in dogfish shark, Squalus acanthias, and its role in rectal gland Cl secretion Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2002; 283(3): R631 - R637. [Abstract] [Full Text] [PDF]

				M. A. Rudd, M. Trolliet, S. Hope, A. W. Scribner, G. Daumerie, G. Toolan, T. Cloutier, and J. Loscalzo Salt-induced hypertension in Dahl salt-resistant and salt-sensitive rats with NOS II inhibition Am J Physiol Heart Circ Physiol, August 1, 1999; 277(2): H732 - H739. [Abstract] [Full Text] [PDF]

				T. Yang, I. Singh, H. Pham, D. Sun, A. Smart, J. B. Schnermann, and J. P. Briggs Regulation of cyclooxygenase expression in the kidney by dietary salt intake Am J Physiol Renal Physiol, March 1, 1998; 274(3): F481 - F489. [Abstract] [Full Text] [PDF]