This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Schmid-Schonbein, G. W. Articles by Chen, P. C. Search for Related Content PubMed PubMed Citation Articles by Schmid-Schonbein, G. W. Articles by Chen, P. C.

Hypertension, Vol 9, 164-171, Copyright © 1987 by American Heart Association

ARTICLES

Microvascular tone in a skeletal muscle of spontaneously hypertensive rats

GW Schmid-Schonbein, BW Zweifach, FA DeLano and PC Chen

We studied the degree of arteriolar smooth muscle constriction in the spinotrapezius muscle microcirculation of spontaneously hypertensive rats and their normotensive controls, Wistar-Kyoto rats. The constriction was expressed in the form of a nondimensional tone as the difference between steady state and dilated diameter (after papaverine treatment) divided by the dilated diameter. Both animal strains showed on average a progressive increase of tone toward the more distal arterioles, with a peak tone being reached in the transverse arterioles. Tone values in the hypertensive animals were consistently elevated. The number of arterioles that had more than 5% tone (so- called responder arterioles) was higher in the hypertensive animals. These studies suggest that, besides the anatomical adjustments documented earlier in our laboratory in the arteriolar network of this muscle, functional adjustments in the form of an elevated microvascular tone are associated with the elevated resistance in spontaneously hypertensive rats.

This article has been cited by other articles:

				I. Rutkai, A. Feher, N. Erdei, D. Henrion, Z. Papp, I. Edes, A. Koller, G. Kaley, and Z. Bagi Activation of prostaglandin E2 EP1 receptor increases arteriolar tone and blood pressure in mice with type 2 diabetes Cardiovasc Res, July 1, 2009; 83(1): 148 - 154. [Abstract] [Full Text] [PDF]

				H. Suzuki, F. A. DeLano, D. A. Parks, N. Jamshidi, D. N. Granger, H. Ishii, M. Suematsu, B. W. Zweifach, and G. W. Schmid-Schonbein Xanthine oxidase activity associated with arterial blood pressure in spontaneously hypertensive rats PNAS, April 14, 1998; 95(8): 4754 - 4759. [Abstract] [Full Text] [PDF]

				H. Suzuki, B. W. Zweifach, and G. W. Schmid-Schonbein Glucocorticoid Modulates Vasodilator Response of Mesenteric Arterioles in Spontaneously Hypertensive Rats Hypertension, January 1, 1996; 27(1): 114 - 118. [Abstract] [Full Text]

				H. Suzuki, B. W. Zweifach, and G. W. Schmid-Schonbein Vasodilator Response of Mesenteric Arterioles to Histamine in Spontaneously Hypertensive Rats Hypertension, September 1, 1995; 26(3): 397 - 400. [Abstract] [Full Text]

				H. Suzuki, A. Swei, B. W. Zweifach, and G. W. Schmid-Schonbein In Vivo Evidence for Microvascular Oxidative Stress in Spontaneously Hypertensive Rats : Hydroethidine Microfluorography Hypertension, May 1, 1995; 25(5): 1083 - 1089. [Abstract] [Full Text]