on June 25, 2007
Published online before print June 25, 2007, doi: 10.1161/HYPERTENSIONAHA.107.091041
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Submitted on March 15, 2007
From the Departments of Nutrition (X.G., L.Q., A.A.), and Epidemiology (G.C., A.A.), Harvard University School of Public Health, Boston, Mass; US Department of Agriculture Human Nutrition Research Center (N.Q., K.L.T.), Tufts University, Boston, Mass; Rheumatology Division (H.K.C.), Department of Medicine, Vancouver General Hospital, University of British Columbia, Vancouver, Canada; and Channing Laboratory (G.C., H.K.C., A.A.), Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Mass. * To whom correspondence should be addressed. E-mail: xgao{at}hsph.harvard.edu.
Abstract--Fructose-induced hyperuricemia might have a causal role in metabolic syndrome, hypertension, and other chronic disease. However, no study has investigated whether sugar added to foods or sugar-sweetened beverages, which are major sources of fructose, are associated with serum uric acid concentration in free-living populations. We examined the relationship between the intakes of added sugars and sugar-sweetened beverages and serum uric acid concentrations in the National Health and Nutrition Examination Survey 2001-2002, a nationally representative sample of men and women. We included 4073 subjects (1988 men and 2085 women) >18 years of age in the current study. Dietary intake was assessed by a single 24-hour recall. We used multivariate linear regression to adjust for age, gender, intake of energy and alcohol, body mass index, use of diuretics,
Revised on April 3, 2007
Intake of Added Sugar and Sugar-Sweetened Drink and Serum Uric Acid Concentration in US Men and Women
Xiang Gao*;
-blockers, and other covariates. Male subjects in the highest intake quartile of estimated intake of added sugars or sugar-sweetened drinks had higher plasma uric acid concentrations than those in the lowest intake quartiles (P<0.001 for both) after adjusting for potential confounders, whereas we did not observe significant associations for females (P for trend>0.2; P for interaction <0.01). Further research is needed to confirm causality of these associations and the observed difference by gender.
Key words: uric acid • beverages • added sugar • fructose • National Health and Nutrition Examination Survey
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