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(Hypertension. 1996;28:1-2.)
© 1996 American Heart Association, Inc.

Articles

Intervention Trials

Concerns and Publishing Pitfalls

Edward D. Frohlich, Editor of Hypertension

Correspondence to Edward D. Frohlich, MD, Alton Ochsner Medical Foundation, 1516 Jefferson Highway, New Orleans, LA 70124.

	Introduction

 
I have just attended a small meeting on intervention trials in hypertension organized by the International and European Societies of Hypertension, the proceedings of which will be published soon in the Journal of Hypertension. I am delighted to see the continued and warm cooperation of our two journals. More specifically, I am continually impressed with how far we have come since our early Veterans Administration Cooperative Studies organized by Edward D. Freis over 30 years ago. During these years we have seen the established efficacy of antihypertensive agents in reducing arterial pressure and controlling outcomes of hypertensive cardiac and vascular diseases. We have seen a reversal of cardiovascular morbidity and mortality that is associated with marked reductions in the prevalence of hypertensive emergencies and accelerated and malignant hypertension and, of course, dramatic reductions in deaths from stroke and coronary heart disease (CHD).

	Data Analyses

 
As we have become well aware, we have been served well by the relatively recent developments in "post hoc analyses" of studies and trials. Nevertheless, cautions were raised at this symposium on the conduct of meta-analysis and the use of drug study databases. One presentation was concerned with the "pros and cons" of meta-analysis, suggesting that perhaps a better term would be "pros and cautions." However, the subject of these analyses might be more appropriately termed "cautions and cons." With the recent plethora of publications employing these and other sophisticated epidemiological and biostatistical techniques, another presentation emphasized the need for more rigorous and careful review, analysis, and . . . [Full Text of this Article]

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