(Hypertension. 1999;34:371.)
© 1999 American Heart Association, Inc.
Editorial |
| Introduction |
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In this month's issue, we honor Sir James W. Black. It was in 1976
that Sir James Black (then head of biological research at Smith Kline &
French Laboratories) received the Ciba Award at the Council for High
Blood Pressure Research meeting. Dr Raymond P. Ahlquisht, PhD, also
received the Ciba Award that year for his exposition of the concept of
alpha- and beta-adrenergic receptor sites; and, Sir James Black was
recognized for the development of beta-adrenergic receptor
antagonists. It was later, in 1988, that Sir James Black
and Doctors Gertrude B. Elion and George H. Hitchings were jointly
honored with the Nobel Prize for their annunciation of the fundamental
concept of the physiological receptor site, leading
to the development of specific receptor-blocking pharmacological agents
that inhibit those naturally occurring
physiological receptor sites. Sir James Black, now
at the King's College Hospital Medical School in London, developed two
important drugs at that time: propanolol,
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