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(Hypertension. 2006;48:804.)
© 2006 American Heart Association, Inc.

Brief Reviews

Vascular Gap Junctions in Hypertension

From the Unidad de Regulación Neurohumoral (X.F.F.), Departamento de Ciencias Fisiológicas, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile; and the Department of Molecular Physiology and Biological Physics (B.E.I., B.R.D.), The Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, Va.

Correspondence to Brian R. Duling, University of Virginia Cardiovascular Research Center, University of Virginia, PO Box 801394, Charlottesville, VA 22908. E-mail brd@virginia.edu

An extract of the first 250 words of the full text is provided, because this article has no abstract.

	Introduction

 
The proteins that form the gap junctions (connexins) are widely expressed in organs that are central to the development of hypertension: endocrine organs, kidney, brain, heart, and vasculature (Figure 1). Surprisingly, there is little information on the modification of connexins in hypertension in any of these organs except the vasculature, the subject of our review, but it would be hoped that this lack of information might spur research on these organs.

View larger version (42K): [in this window] [in a new window]   Figure 1. Possible roles for the connexins in the control of blood pressure. A, Electron micrograph of a longitudinal view of an arteriole. Vascular connexins can play multiple roles in regulating function and vasomotor tone. Cell–cell communication, both radial and longitudinal, links the cells of the arteriolar wall. B, Most every organ involved in the control of blood pressure abundantly expresses 1 of the connexins. Essentially no experimental evidence exists regarding a possible link between connexins and hypertension in nonvascular tissues.

Augmented vasomotor tone typically plays a key role in the development of hypertension, and tone depends on cell–cell communication established by paracrine molecules and, in addition, gap junctions. Paracrine-based linkages between cells of the vasculature are well known, and the possible roles of such linkages in the genesis of hypertension have been extensively explored. Much less is known of the roles of gap junctional communication in establishing vasomotor tone and of the effects of modification of gap junctions on hypertension.

	Structure and Regulation of Gap Junctions

 
The gap junctions are formed by joining 2 hexameric assemblies of connexin protein monomers, that is, . . . [Full Text of this Article]

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